Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
DNA-directed RNA polymerases I, II, and III subunit RPABC3	P52434	[Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.]
Coiled-coil domain-containing protein 106	Q9BWC9	[Function: Promotes the degradation of p53/TP53 protein and inhibits its transactivity.]
DNA-directed RNA polymerase II subunit RPB11-a	P52435	[Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).]
Selenoprotein H	Q3UQA7	[Function: May be involved in a redox-related process.]
Glutamine-rich protein 2	Q3V2A7	[Function: Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility.]
Diacylglycerol kinase epsilon	P52429	[Function: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.]
Nuclear nucleic acid-binding protein C1D	Q13901	[Function: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).]
Isopentenyl-diphosphate Delta-isomerase 1	Q13907	[Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).]
Rap guanine nucleotide exchange factor 1	Q13905	[Function: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.]
Acetyl-CoA acetyltransferase, cytosolic	Q9BWD1	[Function: Involved in the biosynthetic pathway of cholesterol.]
Exocrine gland-secreted peptide 22	A8R0V4	[Function: Pheromone produced by juveniles which activates a small number of vomeronasal organ sensory neurons and exhibits a powerful inhibitory effect on adult male mating behavior.]
Retrotransposon Gag-like protein 8A	Q9BWD3
Thioredoxin domain-containing protein 12	Q498E0	[Function: Possesses significant protein thiol-disulfide oxidase activity.]
Beta-enolase	P15429	[Function: Appears to have a function in striated muscle development and regeneration.]
15-hydroxyprostaglandin dehydrogenase [NAD(+)]	P15428	[Function: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.]
Glycophorin-E	P15421	[Function: This protein is a minor sialoglycoprotein in human erythrocyte membranes.]
F-box/WD repeat-containing protein 7	D3Z902	[Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and probably PSEN1 (By similarity). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (By similarity). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (By similarity).]
Gamma-aminobutyric acid receptor subunit beta-1	P15431	[Function: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.]
Replication initiator 1	Q9BWE0	[Function: Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending.]
Testis development-related protein	Q498E2	[Function: Contributes to normal sperm motility, but not essential for male fertility.]