Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Methyltransferase-like protein 22	Q9BUU2	[Function: Protein N-lysine methyltransferase. In vitro methylates KIN.]
E3 ubiquitin-protein ligase RNF126	Q9BV68	[Function: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).]
Alpha-(1,3)-fucosyltransferase 5	Q11128	[Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.]
Alpha-(1,3)-fucosyltransferase 4	Q11127	[Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.]
Coiled-coil domain-containing protein 61	Q9Y6R9
Ankyrin repeat domain-containing protein 53	Q3V0J4	[Function: Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.]
Transmembrane protein 237	Q3V0J1	[Function: Component of the transition zone in primary cilia. Required for ciliogenesis.]
Mitogen-activated protein kinase kinase kinase 4	Q9Y6R4	[Function: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.]
Zinc finger protein 780B	Q9Y6R6	[Function: May be involved in transcriptional regulation.]
IgGFc-binding protein	Q9Y6R7	[Function: May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.]
Solute carrier family 25 member 34	A2ADF7
MAPK regulated corepressor interacting protein 2	Q9BUT9
Apolipoprotein F	Q13790	[Function: Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.]
Alpha-(1,3)-fucosyltransferase 7	Q11131	[Function: Catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.]
Alpha-(1,3)-fucosyltransferase 7	Q11130	[Function: Catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.]
Serine/threonine-protein kinase 24	Q9Y6E0	[Function: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.]
Iron-sulfur cluster assembly 1 homolog, mitochondrial	Q9BUE6	[Function: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.]
Basic leucine zipper and W2 domain-containing protein 2	Q9Y6E2	[Function: May be involved in neuronal differentiation.]
Small integral membrane protein 9	Q3V0X1
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial	Q9Y6E7	[Function: Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Does not seem to deacetylate PC (PubMed:23438705). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310). Down-regulates insulin secretion.]