Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Nucleolar transcription factor 1	P17480	[Function: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.]
DISP complex protein LRCH3	Q8BVU0	[Function: As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton.]
Interleukin-12 subunit alpha	P29459	[Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.]
Zinc finger protein 92	Q03936	[Function: May be involved in transcriptional regulation.]
Ankyrin and armadillo repeat-containing protein	A2RT91
Serpin H1	P29457	[Function: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.]
Protein STPG3	A2RSX4
Zinc finger protein 90	Q03938	[Function: May be involved in transcriptional regulation.]
Uncharacterized protein C7orf31	Q8N865
Interleukin-10	P29456	[Function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).]
Tetra-peptide repeat homeobox protein 1	Q8N7U7
von Willebrand factor A domain-containing protein 5A	Q75WE7	[Function: May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in may contribute directly to or modify tumorigenesis (By similarity).]
EF-hand domain-containing family member B	Q8N7U6	[Function: Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.]
Zinc finger protein 77	Q15935	[Function: May be involved in transcriptional regulation.]
Putative uncharacterized protein encoded by LINC00469	Q8N7U9
Caspase-1	P29452	[Function: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (By similarity).]
Zinc finger protein 79	Q15937	[Function: May be involved in transcriptional regulation.]
Cytochrome b-c1 complex subunit 8	Q7TQ16	[Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone (By similarity).]
Centrosomal protein of 95 kDa	Q8BVV7
Alpha-1-antiproteinase	P17475	[Function: Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin.]