Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| 26S proteasome non-ATPase regulatory subunit 2 | Q13200 | [Function: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.] |
| Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 | D3YZG8 | |
| Multimerin-1 | Q13201 | [Function: Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein.] |
| Protein fantom | Q68CZ1 | [Function: Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (PubMed:19464661). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (PubMed:19464661). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (By similarity). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (By similarity).] |
| Protein FAM216B | Q8N7L0 | |
| Probable ATP-dependent RNA helicase DDX10 | Q13206 | [Function: Putative ATP-dependent RNA helicase.] |
| Janus kinase and microtubule-interacting protein 1 | Q8BVL9 | [Function: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.] |
| Enolase-phosphatase E1 | Q5PPH0 | [Function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).] |
| T-box transcription factor TBX2 | Q13207 | [Function: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation.] |
| HAUS augmin-like complex subunit 3 | Q68CZ6 | [Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.] |
| G-protein coupled receptor 55 | Q3UJF0 | [Function: Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA (By similarity). Putative cannabinoid receptor (By similarity). May play a role in bone physiology by regulating osteoclast number and function (By similarity). May be involved in hyperalgesia associated with inflammatory and neuropathic pain.] |
| Sorting nexin-17 | Q8BVL3 | [Function: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:12169628, PubMed:16052210). Binds to NPxY sequences in the cytoplasmic tails of target cargos (By similarity). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (By similarity). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16052210, PubMed:18276590). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).] |
| Chemokine-like protein TAFA-1 | Q7TPG8 | [Function: Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation.] |
| Chemokine-like protein TAFA-3 | Q7TPG6 | [Function: Plays a role in the regulation of microglia polarization.] |
| Chemokine-like protein TAFA-2 | Q7TPG7 | [Function: Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions.] |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Q01237 | [Function: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.] |
| Chemokine-like protein TAFA-4 | Q7TPG5 | [Function: Modulates injury-induced and chemical pain hypersensitivity (PubMed:24139797). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685).] |
| Zinc finger protein 414 | Q5PPH4 | [Function: May be involved in transcriptional regulation.] |
| Mitogen-activated protein kinase kinase kinase 1 | Q13233 | [Function: Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).] |
| Uncharacterized protein C5orf34 homolog | Q3UJC8 |