Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Protein STPG4	Q8N801	[Function: Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).]
Vesicle-associated membrane protein 3	Q15836	[Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.]
Natural cytotoxicity triggering receptor 3 ligand 1	Q68D85	[Function: Triggers NCR3-dependent natural killer cell activation.]
DENN domain-containing protein 3	A2RT67	[Function: Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939). Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330). Starvation also induces phosphorylation at Tyr-940, which leads to up-regulated GEF activity and initiates autophagy (PubMed:28249939).]
Rhodopsin kinase GRK1	Q15835	[Function: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).]
Coiled-coil domain-containing protein 85B	Q15834	[Function: (Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication.]
Syntaxin-binding protein 2	Q15833	[Function: Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.]
Protein disulfide-isomerase-like protein of the testis	Q8N807	[Function: Probable redox-inactive chaperone involved in spermatogenesis.]
Putative E3 ubiquitin-protein ligase UBR7	Q8N806	[Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.]
Solute carrier family 35 member G3	Q8N808
Spindle and centriole-associated protein 1	Q8C804	[Function: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.]
Translocon-associated protein subunit alpha	Q7TPJ0	[Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins (By similarity).]
Protocadherin alpha-4	Q767I8	[Function: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.]
RNA-binding protein NOB1	Q8BW10	[Function: May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).]
Probable E3 ubiquitin-protein ligase TRIML1	Q8BVP1	[Function: Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development. Involved in progression of blastocyst stage and subsequent embryo development.]
Solute carrier family 35 member E2A	Q8C811	[Function: Putative transporter.]
Putative inactive serine protease 58	Q8BW11
Coiled-coil domain-containing protein 102B	Q68D86
Serine protease HTRA4	A2RT60	[Function: Serine protease.]
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	Q6U7H8	[Function: May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.]