Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Pancreas/duodenum homeobox protein 1 | P52947 | [Function: Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.] |
| Homeobox protein Hox-A5 | P52949 | [Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity).] |
| Disintegrin and metalloproteinase domain-containing protein 1a | Q60813 | [Function: May be involved in sperm-egg fusion.] |
| Cytoplasmic dynein 2 heavy chain 1 | Q8NCM8 | [Function: May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity).] |
| C-type lectin domain family 10 member A | P49301 | [Function: Recognizes terminal galactose and N-acetylgalactosamine units.] |
| Small integral membrane protein 18 | P0DKX4 | |
| Nuclear autoantigenic sperm protein | P49321 | [Function: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.] |
| Zinc finger protein 728 | P0DKX0 | |
| LIX1-like protein | Q8IVB5 | |
| Binder of sperm protein homolog 1 | Q3UW26 | [Function: Binds sperm in vitro and promotes sperm capacitation (PubMed:22539676, PubMed:24307707). Specifically promotes capacitation induced by high density lipoproteins (HDLs) (PubMed:25602034). Also binds heparin, phospholipid liposomes, and weakly to gelatin (PubMed:22539676). Does not bind chondroitin sulfate B (PubMed:22539676).] |
| F-actin-capping protein subunit alpha-2 | Q3T1K5 | [Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).] |
| Sodium/hydrogen exchanger 9 | Q8IVB4 | [Function: May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.] |
| Keratin, type I cuticular Ha7 | O76014 | |
| Keratin, type I cuticular Ha8 | O76015 | |
| Colipase-like protein 2 | Q3UW21 | |
| Keratin, type I cuticular Ha6 | O76013 | |
| Keratin, type I cuticular Ha4 | O76011 | |
| E3 ubiquitin-protein ligase RNF168 | B2RYR0 | [Function: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).] |
| CCR4-NOT transcription complex subunit 7 | Q60809 | [Function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.] |
| Zinc finger and BTB domain-containing protein 34 | Q8NCN2 | [Function: May be a transcriptional repressor.] |