Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Myotubularin-related protein 12	Q9C0I1	[Function: Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity).]
Coiled-coil domain-containing protein 185	Q8N715
Homeobox protein HMX2	A2RU54	[Function: Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.]
Interleukin-22 receptor subunit alpha-1	Q8N6P7	[Function: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.]
ETS-related transcription factor Elf-2	Q15723	[Function: Isoform 2 may function in repression of RUNX1-mediated transactivation.]
Protein YIPF3	Q6TUD4	[Function: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity).]
Zinc finger protein 57	Q8C6P8	[Function: Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:15070898, PubMed:18854139, PubMed:23059534, PubMed:30602440). Acts together with ZNF445, but ZFP57 plays the predominant role in imprinting maintenance. In contrast, in humans, ZNF445 seems to be the major factor early embryonic imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (PubMed:15070898, PubMed:18854139, PubMed:23059534).]
Protein FAM43A	Q8BUP8
Transmembrane protein 65	Q6PI78	[Function: May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance (PubMed:28295037).]
Rho GTPase-activating protein 39	Q9C0H5
Protein tweety homolog 3	Q9C0H2	[Function: Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction.]
SRC kinase signaling inhibitor 1	Q9C0H9	[Function: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.]
Kelch-like protein 4	Q9C0H6
Pro-neuregulin-3, membrane-bound isoform	P56975	[Function: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.]
Pro-neuregulin-2, membrane-bound isoform	P56974	[Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	P54313	[Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.]
Hormone-sensitive lipase	P54310	[Function: In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.]
C-X-C motif chemokine 2	P30348	[Function: Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	P54311	[Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.]
Leukotriene A-4 hydrolase	P30349	[Function: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.]