Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Ubiquinone biosynthesis protein COQ9, mitochondrial | Q68FT1 | [Function: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.] |
| Succinate receptor 1 | Q6IYF9 | [Function: Receptor for succinate.] |
| 2-oxoglutarate receptor 1 | Q6IYF8 | [Function: Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway.] |
| Ammonium transporter Rh type B | Q68FT6 | [Function: Functions as a specific ammonium transporter.] |
| S-methylmethionine--homocysteine S-methyltransferase BHMT2 | Q68FT5 | [Function: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity).] |
| Hairy and enhancer of split-related protein HELT | Q7TS99 | [Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Required for the development of GABAergic neurons.] |
| Nuclear receptor subfamily 2 group E member 1 | Q9Y466 | [Function: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells.] |
| Suppressor of IKBKE 1 | Q9BRV8 | [Function: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.] |
| Sal-like protein 2 | Q9Y467 | [Function: Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure.] |
| Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | [Function: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.] |
| 60S ribosomal protein L36 | Q9Y3U8 | [Function: Component of the large ribosomal subunit.] |
| Zinc finger protein 711 | Q9Y462 | [Function: Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.] |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Q9Y463 | [Function: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).] |
| Talin-2 | Q71LX4 | [Function: As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).] |
| Cytochrome c oxidase subunit 6B2 | Q6YFQ1 | [Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase (By similarity).] |
| Sugar transporter SWEET1 | Q9BRV3 | [Function: Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.] |
| Cytochrome c oxidase subunit 6B2 | Q6YFQ2 | [Function: Connects the two COX monomers into the physiological dimeric form.] |
| Cytochrome c oxidase subunit 7C, mitochondrial | P17665 | [Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.] |
| Transmembrane protein 183 | Q68FS7 | |
| Zinc finger protein 587B | E7ETH6 | [Function: May be involved in transcriptional regulation.] |