Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Cysteine protease ATG4A	Q8C9S8	[Function: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity).]
Regulator of G-protein signaling 8	Q8BXT1	[Function: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.]
Leucine zipper putative tumor suppressor 2	Q9BRK4	[Function: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.]
45 kDa calcium-binding protein	Q9BRK5	[Function: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.]
Matrix remodeling-associated protein 8	Q9BRK3	[Function: (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses.]
Putative uncharacterized protein CXorf42	Q8N9T2
Putative postmeiotic segregation increased 2-like protein 3	Q13401
Ubiquitin-conjugating enzyme E2 variant 1	Q13404	[Function: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:31006531).]
39S ribosomal protein L49, mitochondrial	Q13405
Protein KRI1 homolog	Q8N9T8
Unconventional myosin-VIIa	Q13402	[Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.]
Paraplegin	Q3ULF4	[Function: ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (By similarity).]
Cytoplasmic dynein 1 intermediate chain 2	Q13409	[Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. Has a critical role in neurodevelopment (PubMed:31079899).]
Vesicle-trafficking protein SEC22c	Q8BXT9	[Function: May be involved in vesicle transport between the ER and the Golgi complex.]
AMP deaminase 2	Q01433	[Function: AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.]
AMP deaminase 3	Q01432	[Function: AMP deaminase plays a critical role in energy metabolism.]
Serine/arginine-rich splicing factor 8	Q9BRL6	[Function: Involved in pre-mRNA alternative splicing.]
Vesicle-trafficking protein SEC22c	Q9BRL7	[Function: May be involved in vesicle transport between the ER and the Golgi complex.]
Zinc transporter ZIP6	Q13433	[Function: May act as a zinc-influx transporter.]
Putative E3 ubiquitin-protein ligase makorin-4	Q13434	[Function: May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.]