Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Transmembrane protein 87A | Q8BXN9 | [Function: May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).] |
| Activating signal cointegrator 1 complex subunit 1 | Q8N9N2 | [Function: Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.] |
| Protein phosphatase 1K, mitochondrial | Q8BXN7 | [Function: Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.] |
| Cytosolic iron-sulfur assembly component 2B | Q9Y3D0 | [Function: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633).] |
| Protein BANP | Q8N9N5 | [Function: Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).] |
| Probable RNA-binding protein EIF1AD | Q8N9N8 | [Function: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.] |
| Leucine-rich repeat-containing protein 57 | Q8N9N7 | |
| 28S ribosomal protein S18c, mitochondrial | Q9Y3D5 | |
| Serine/threonine-protein phosphatase CPPED1 | Q9BRF8 | [Function: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.] |
| Mitochondrial fission 1 protein | Q9Y3D6 | [Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.] |
| Mitochondrial import inner membrane translocase subunit TIM16 | Q9Y3D7 | [Function: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.] |
| Adenylate kinase isoenzyme 6 | Q9Y3D8 | [Function: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.] |
| Coiled-coil domain-containing protein 106 | Q3ULM0 | [Function: Promotes the degradation of p53/TP53 protein and inhibits its transactivity.] |
| Methionine-R-sulfoxide reductase B2, mitochondrial | Q9Y3D2 | [Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.] |
| 28S ribosomal protein S16, mitochondrial | Q9Y3D3 | |
| 28S ribosomal protein S23, mitochondrial | Q9Y3D9 | |
| Probable ATP-dependent RNA helicase DDX60-like | Q5H9U9 | |
| Thyroxine-binding globulin | P05543 | [Function: Major thyroid hormone transport protein in serum.] |
| Inner nuclear membrane protein Man1 | Q9Y2U8 | [Function: Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.] |
| Serine protease inhibitor A3L | P05544 |