Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Tetraspanin-12	O95859	[Function: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.]
Tubulin epsilon and delta complex protein 2	Q6GQV0	[Function: Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability.]
INSYN2B protein	Q6GQV1
Tetraspanin-13	O95857
Tetraspanin-15	O95858	[Function: Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).]
Protein SGT1 homolog	Q9Y2Z0	[Function: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.]
COMM domain-containing protein 2	Q8BXC6	[Function: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B.]
Protein MTO1 homolog, mitochondrial	Q9Y2Z2	[Function: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.]
Proto-oncogene Mas	P30554	[Function: Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (By similarity). Receptor for angiotensin 1-7.]
Angiopoietin-related protein 1	O95841
Type-1 angiotensin II receptor	P30556	[Function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.]
Prostaglandin E2 receptor EP3 subtype	P30557	[Function: Receptor for prostaglandin E2 (PGE2); ligand binding can activate several distinct signaling cascades, resulting in activation or inhibition of adenylate cyclase.]
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3	Q6GQU6
Proteinase-activated receptor 1	P30558	[Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.]
Palmitoyltransferase ZDHHC9	Q9Y397	[Function: The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.]
ARF GTPase-activating protein GIT1	Q9Y2X7	[Function: GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13 (By similarity).]
Oxytocin receptor	P30559	[Function: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.]
Ubiquitin-conjugating enzyme E2 D4	Q9Y2X8	[Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.]
Zinc finger protein 281	Q9Y2X9	[Function: Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.]
28S ribosomal protein S2, mitochondrial	Q9Y399	[Function: Required for mitoribosome formation and stability, and mitochondrial translation.]