Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Polyribonucleotide 5'-hydroxyl-kinase Clp1	Q5PQL4	[Function: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).]
Phosphatidylserine synthase 1	Q5PQL5	[Function: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).]
Pleckstrin homology domain-containing family A member 6	Q7TQG1
WD40 repeat-containing protein SMU1	Q3UKJ7	[Function: Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).]
Zinc finger protein 491	Q8N8L2	[Function: May be involved in transcriptional regulation.]
RNA-binding motif, single-stranded-interacting protein 3	Q8BWL5	[Function: Binds poly(A) and poly(U) oligoribonucleotides.]
Zinc finger and BTB domain-containing protein 5	Q7TQG0	[Function: May be involved in transcriptional regulation.]
Microtubule-associated protein 1A	P78559	[Function: Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.]
ADP-ribosylation factor-like protein 10	Q8N8L6
WD repeat-containing protein 27	A2RRH5
TP53-target gene 5 protein	Q9Y2B4	[Function: May play a significant role in p53/TP53-mediating signaling pathway.]
Uncharacterized protein KIAA1958	Q8N8K9
Adenine nucleotide translocase lysine N-methyltransferase	Q9BQD7	[Function: Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526).]
VPS9 domain-containing protein 1	Q9Y2B5
Kita-kyushu lung cancer antigen 1	Q5H943
Protein canopy homolog 2	Q9Y2B0	[Function: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.]
Ribitol-5-phosphate xylosyltransferase 1	Q9Y2B1	[Function: UDP-xylosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:27601598, PubMed:27733679) (Probable). Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan (PubMed:27733679, PubMed:29477842) (Probable).]
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase	Q9Y2B2	[Function: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.]
Phospholipase D1	Q13393	[Function: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).]
Integral membrane protein 2C	Q5PQL7	[Function: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).]