Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Mevalonate kinase | Q03426 | [Function: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:9325256, PubMed:18302342).] |
| 60S ribosomal protein L35 | P17078 | [Function: Component of the large ribosomal subunit.] |
| Apolipoprotein D | P05090 | [Function: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.] |
| Coiled-coil domain-containing protein 114 | B1H228 | [Function: Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms.] |
| 60S ribosomal protein L9 | P17077 | |
| Aldehyde dehydrogenase, mitochondrial | P05091 | |
| DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 | Q6EEV4 | |
| Steroid 17-alpha-hydroxylase/17,20 lyase | P05093 | [Function: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938). Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (PubMed:9452426, PubMed:25301938) (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938). Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis (PubMed:27339894, PubMed:25301938). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938).] |
| Amyloid-beta A4 precursor protein-binding family B member 1 | Q9QXJ1 | [Function: Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).] |
| 40S ribosomal protein S19 | P17074 | [Function: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.] |
| Tubulin--tyrosine ligase | Q9QXJ0 | [Function: Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.] |
| Small ubiquitin-related modifier 4 | Q6EEV6 | [Function: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.] |
| ADP-ribosylation factor-like protein 10 | Q9QXJ4 | |
| Sodium/bile acid cotransporter 4 | Q3UEZ8 | [Function: Transporter for bile acids.] |
| Sec1 family domain-containing protein 1 | Q8BRF7 | [Function: Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).] |
| Kelch-like protein 30 | Q8C3F7 | |
| Nuclear receptor subfamily 6 group A member 1 | Q15406 | [Function: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).] |
| Maturin | Q8N3F0 | [Function: Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536' (PubMed:24681962). May be involved in early neuronal development (By similarity).] |
| Ras suppressor protein 1 | Q15404 | [Function: Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.] |
| Constitutive coactivator of PPAR-gamma-like protein 2 | Q8C3F2 |