Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Telomere-associated protein RIF1 | Q5UIP0 | [Function: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity).] |
| Ankyrin repeat and MYND domain-containing protein 2 | Q8IV38 | [Function: May be involved in the trafficking of signaling proteins to the cilia.] |
| Armadillo repeat-containing protein 8 | Q8IUR7 | [Function: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.] |
| Serine protease HTRA3 | D3ZA76 | [Function: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity).] |
| Protein HID1 | Q8IV36 | [Function: May play an important role in the development of cancers in a broad range of tissues.] |
| CREB3 regulatory factor | Q8IUR6 | [Function: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.] |
| WD repeat-containing protein 49 | Q8IV35 | |
| Protein O-mannosyl-transferase TMTC1 | Q8IUR5 | [Function: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.] |
| Uncharacterized protein KIAA0825 | Q8IV33 | |
| Coiled-coil domain-containing protein 71 | Q8IV32 | |
| Transmembrane protein 139 | Q8IV31 | [Function: May be involved in cellular trafficking of proteins such as SLC4A1.] |
| Trafficking protein particle complex subunit 5 | Q8IUR0 | [Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi.] |
| Semaphorin-3E | O15041 | [Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).] |
| Tectonin beta-propeller repeat-containing protein 2 | O15040 | [Function: Probably plays a role as positive regulator of autophagy.] |
| U2 snRNP-associated SURP motif-containing protein | O15042 | |
| 3'-5' exoribonuclease 1 | Q8IV48 | [Function: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.] |
| Epoxide hydrolase 4 | Q8IUS5 | |
| UNC5C-like protein | Q8IV45 | [Function: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.] |
| DCN1-like protein 4 | Q8CCA0 | |
| Protein KHNYN | O15037 |