Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Interleukin-11 receptor subunit alpha-1	Q64385	[Function: A soluble form (sIL11RA) can act as an antagonist of IL11-dependent cell differentiation in cells where both transmembrane IL11RA and IL6ST are present.]
Prepronociceptin	Q64387	[Function: Has potent analgesic activity.]
Rho GTPase-activating protein 28	Q9P2N2	[Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.]
CAMPATH-1 antigen	Q64389	[Function: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.]
A disintegrin and metalloproteinase with thrombospondin motifs 9	Q9P2N4	[Function: Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-\|-Ala-1839' site) and versican (at the '1428-Glu-\|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.]
RNA-binding protein 27	Q9P2N5
KAT8 regulatory NSL complex subunit 3	Q9P2N6	[Function: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.]
Rab11 family-interacting protein 4	Q8BQP8	[Function: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development, in a Rab11-independent manner.]
Kelch-like protein 13	Q9P2N7	[Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.]
Kinesin-like protein KIFC1	Q9QWT9	[Function: Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:16638812). May contribute to movement of early endocytic vesicles (PubMed:17360972). Regulates cilium formation and structure (PubMed:23807208).]
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like	Q8C2P3	[Function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.]
Shieldin complex subunit 2	Q3UEN2	[Function: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.]
E3 ubiquitin-protein ligase RNF128	Q8TEB7	[Function: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.]
Roundabout homolog 4	Q8C310	[Function: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins.]
DDB1- and CUL4-associated factor 11	Q8TEB1	[Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.]
Small vasohibin-binding protein	Q8N300	[Function: Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017).]
40-kDa huntingtin-associated protein	M0RDU0	[Function: RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility.]
Angiogenic factor with G patch and FHA domains 1	Q8N302	[Function: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.]
Acetylcholine receptor subunit gamma	P07510	[Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.]
Uncharacterized protein C6orf223	Q8N319