Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Disintegrin and metalloproteinase domain-containing protein 8 | Q05910 | [Function: Possible involvement in extravasation of leukocytes.] |
| RAB6A-GEF complex partner protein 1 | Q4ADV7 | [Function: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.] |
| Transmembrane protein 181 | Q9P2C4 | [Function: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.] |
| GTP cyclohydrolase 1 | Q05915 | [Function: May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence.] |
| Heparan-alpha-glucosaminide N-acetyltransferase | Q3UDW8 | [Function: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.] |
| SRC kinase signaling inhibitor 1 | Q9QWI6 | [Function: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity).] |
| Eukaryotic translation initiation factor 3 subunit M | Q7L2H7 | [Function: (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).] |
| F-box/LRR-repeat protein 15 | D4ABB4 | [Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance.] |
| Metalloproteinase inhibitor 4 | P81556 | [Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.] |
| Immunoglobulin superfamily DCC subclass member 4 | Q8TDY8 | |
| RB1-inducible coiled-coil protein 1 | Q8TDY2 | [Function: Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).] |
| Actin-related protein T2 | Q8TDY3 | |
| Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Q8TDY4 | [Function: Promotes cell proliferation.] |
| Ly6/PLAUR domain-containing protein 1 | Q8N2G4 | [Function: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety.] |
| Mycophenolic acid acyl-glucuronide esterase, mitochondrial | Q6PE15 | |
| Zinc finger CCHC domain-containing protein 24 | Q8N2G6 | |
| Proline-rich transmembrane protein 3 | Q6PE13 | |
| GH3 domain-containing protein | Q8N2G8 | |
| Kelch-like protein 2 | O95198 | [Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.] |
| Probable phospholipid-transporting ATPase IIB | D4ABB8 |