Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
INO80 complex subunit B	Q9C086	[Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.]
Lanosterol 14-alpha demethylase	Q64654	[Function: Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.]
Ataxin-8	Q156A1
Beta-defensin 50	Q6TU36	[Function: Has bactericidal activity.]
GTPase RhebL1	Q7TNZ5	[Function: Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity).]
STE20-related kinase adapter protein alpha	Q7TNZ6	[Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).]
Dendritic cell-specific transmembrane protein	Q7TNJ0	[Function: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.]
Calcium/calmodulin-dependent protein kinase type 1G	Q7TNJ7	[Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).]
Translocating chain-associated membrane protein 1-like 1	Q8N609	[Function: Stimulatory or required for the translocation of secretory proteins across the ER membrane.]
Protein BHLHb9	Q6PI77	[Function: May play a role in the control of cellular aging and survival.]
Inactive dipeptidyl peptidase 10	Q8N608	[Function: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).]
Leukocyte immunoglobulin-like receptor subfamily A member 6	Q6PI73	[Function: May act as receptor for class I MHC antigens.]
Amphoterin-induced protein 2	Q7TNJ4	[Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain.]
ATP-binding cassette sub-family A member 7	Q7TNJ2	[Function: ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (By similarity). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (By similarity). May also mediate cholesterol efflux (By similarity). May regulate cellular ceramide homeostasis during keratinocyte differentiation (By similarity). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (By similarity).]
CUB and zona pellucida-like domain-containing protein 1	Q9QZT0	[Function: CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may play a role in these processes. May play a role in trypsin activation in pancreatic acinar cells. May also play a role in the uterus during late pregnancy (By similarity).]
Protein FAM167B	P17257
Group 10 secretory phospholipase A2	Q9QZT3	[Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids (By similarity).]
Mevalonate kinase	P17256	[Function: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.]
Cell surface glycoprotein CD200 receptor 5	Q8BTP3	[Function: May not be a receptor for the CD200/OX2 cell surface glycoprotein.]
Translocation protein SEC62	Q8BU14	[Function: Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.]