Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Protein shisa-9	B4DS77	[Function: Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).]
Rho guanine nucleotide exchange factor 39	Q8N4T4	[Function: Promotes cell proliferation.]
Zinc finger protein 276	Q8N554	[Function: May be involved in transcriptional regulation.]
Adenine phosphoribosyltransferase	P07741	[Function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.]
Protein SPHAR	Q15513
DnaJ homolog subfamily B member 7	Q9QYI8	[Function: Probably acts as a co-chaperone.]
Corneodesmosin	Q15517	[Function: Important for the epidermal barrier integrity.]
Spermatogenesis-associated protein 21	Q68A65	[Function: Involved in the differentiation of haploid spermatids.]
Transmembrane protein 233	D3Z1U7
Regulator of microtubule dynamics protein 2	Q8BSE0
ASNSD1 upstream open reading frame protein	L0R819
Phosducin-like protein 2	Q8N4E4	[Function: May play a role in germ cell maturation.]
Spindlin-4	Q56A73	[Function: Exhibits H3K4me3-binding activity.]
Lamina-associated polypeptide 2, isoforms beta/gamma	P42167	[Function: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.]
Tyrosine-protein kinase ITK/TSK	Q03526	[Function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Phosphorylates TBX21 at 'Tyr-525' and mediates its interaction with GATA3 (PubMed:15662016).]
Lamina-associated polypeptide 2, isoform alpha	P42166	[Function: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.]
Gamma-aminobutyric acid receptor subunit alpha-6	P30191	[Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.]
DnaJ homolog subfamily A member 2	Q9QYJ0	[Function: Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).]
Ras GTPase-activating protein 3	Q9QYJ2	[Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) (By similarity).]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	Q9QYJ1	[Function: Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than with glycoproteins.]