Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Cyclin-K | O75909 | [Function: Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).] |
| Rho guanine nucleotide exchange factor 10 | Q8C033 | [Function: May play a role in developmental myelination of peripheral nerves.] |
| Diacylglycerol O-acyltransferase 1 | O75907 | [Function: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.] |
| Periostin | Q15063 | [Function: Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).] |
| Sterol O-acyltransferase 2 | O75908 | [Function: Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.] |
| Peroxisomal acyl-coenzyme A oxidase 1 | Q15067 | [Function: Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (PubMed:17458872, PubMed:17603022). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (PubMed:17603022). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (PubMed:17603022). Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA (PubMed:17603022).] |
| Leucine-rich repeat-containing protein 4C | Q8C031 | [Function: May promote neurite outgrowth of developing thalamic neurons.] |
| Diacylglycerol kinase iota | O75912 | |
| Membrane protein MLC1 | Q15049 | [Function: Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.] |
| Short-chain dehydrogenase/reductase 3 | O75911 | [Function: Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.] |
| Leucine-rich repeat-containing protein 14 | Q15048 | [Function: Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.] |
| COMM domain-containing protein 9 | Q9P000 | [Function: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).] |
| Histone-lysine N-methyltransferase SETD7 | Q8VHL1 | [Function: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.] |
| Urea transporter 1 | Q8VHL0 | [Function: Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.] |
| Protein cornichon homolog 4 | Q9P003 | [Function: Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).] |
| Putative uncharacterized protein C10orf113 | Q5VZT2 | |
| Macrosialin | P34810 | [Function: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.] |
| Fibronectin type III domain-containing protein 9 | Q8TBE3 | |
| Interleukin-13 receptor subunit alpha-2 | Q8VHK6 | [Function: Binds as a monomer with high affinity to interleukin-13 (IL13).] |
| Membrane protein MLC1 | Q8VHK5 | [Function: Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.] |