Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
SCO-spondin	Q8CG65	[Function: Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).]
Prolactin-releasing peptide receptor	P49683	[Function: Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.]
CMRF35-like molecule 7	A8K4G0	[Function: Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.]
ZZ-type zinc finger-containing protein 3	Q8IYH5	[Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.]
Bestrophin-4	Q8NFU0	[Function: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.]
Bestrophin-2	Q8NFU1	[Function: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.]
Follicular dendritic cell secreted peptide	Q8NFU4	[Function: Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.]
Thiosulfate_glutathione sulfurtransferase	Q8NFU3	[Function: Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631).]
Shieldin complex subunit 1	Q8IYI0	[Function: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.]
Elongin-A3	Q8NG57	[Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).]
Protein DBF4 homolog B	Q8NFT6	[Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.]
Delta and Notch-like epidermal growth factor-related receptor	Q8NFT8	[Function: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).]
Steroidogenic acute regulatory protein, mitochondrial	P49675	[Function: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.]
Ankyrin repeat domain-containing protein 20B	Q5CZ79
Riboflavin kinase	Q8CFV9	[Function: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase (By similarity).]
Apoptosis-stimulating of p53 protein 2	Q8CG79	[Function: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (By similarity). Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 (By similarity).]
Protein fantom	Q8CG73	[Function: Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (PubMed:22927466). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (PubMed:26150391).]
Cytosolic phospholipase A2 gamma	Q64GA5	[Function: Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.]
Neuritin	Q8CFV4	[Function: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.]
Aflatoxin B1 aldehyde reductase member 2	Q8CG76	[Function: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).]