Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Isocitrate dehydrogenase [NADP] cytoplasmic | O75874 | |
| Carcinoembryonic antigen-related cell adhesion molecule 4 | O75871 | [Function: Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles.] |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Q99N99 | [Function: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.] |
| Transmembrane gamma-carboxyglutamic acid protein 3 | Q6PAQ9 | |
| Cystathionine beta-synthase | P32232 | [Function: Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (PubMed:20149843, PubMed:8558235).] |
| Dystonin | Q03001 | [Function: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.] |
| Olfactory receptor 1052 | Q8VGR8 | [Function: Potential odorant receptor.] |
| Uncharacterized protein C9orf43 | Q8TAL5 | |
| Transmembrane protein 121B | Q99MX7 | |
| Fin bud initiation factor homolog | Q8TAL6 | |
| Histone deacetylase 8 | Q8VH37 | [Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (By similarity).] |
| Serine hydroxymethyltransferase, mitochondrial | P34897 | [Function: Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:29364879, PubMed:25619277). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29452640, PubMed:29364879). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985).] |
| 39S ribosomal protein L3, mitochondrial | Q99N95 | |
| RNA exonuclease 4 | Q6PAQ4 | [Function: May function as an exonuclease.] |
| Beta-defensin 131B | A0A096LNP1 | [Function: Has antibacterial activity.] |
| Developmentally-regulated GTP-binding protein 1 | P32233 | [Function: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions.] |
| 39S ribosomal protein L1, mitochondrial | Q99N96 | |
| Ret finger protein-like 4A | Q8VH31 | |
| 39S ribosomal protein L16, mitochondrial | Q99N93 | |
| Serine hydroxymethyltransferase, cytosolic | P34896 | [Function: Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).] |