Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
G-protein coupled estrogen receptor 1	Q8BMP4	[Function: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.]
UPF0500 protein C1orf216	Q8TAB5
Propionyl-CoA carboxylase beta chain, mitochondrial	Q99MN9	[Function: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).]
Putative coiled-coil domain-containing protein 26	Q8TAB7
Dual specificity protein phosphatase 22	Q99N11	[Function: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK).]
Membrane-spanning 4-domains subfamily A member 8	Q99N10	[Function: May be involved in signal transduction as a component of a multimeric receptor complex.]
Keratin, type II cytoskeletal 72	Q6IME9	[Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).]
Membrane-spanning 4-domains subfamily A member 6C	Q99N08	[Function: May be involved in signal transduction as a component of a multimeric receptor complex.]
Josephin-2	Q8TAC2	[Function: Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.]
Olfactory receptor 481	Q8VGI5	[Function: Potential odorant receptor.]
Olfactory receptor 476	Q8VGI4	[Function: Potential odorant receptor.]
Membrane-spanning 4-domains subfamily A member 6B	Q99N09	[Function: May be involved in signal transduction as a component of a multimeric receptor complex.]
Solute carrier family 22 member 13	Q6A4L0
Membrane-spanning 4-domains subfamily A member 6D	Q99N07	[Function: May be involved in signal transduction as a component of a multimeric receptor complex.]
Olfactory receptor 477	Q8VGI6	[Function: Potential odorant receptor.]
Olfactory receptor 1	Q8VGI1	[Function: Odorant receptor. Activated by a lily-derived aldehyde as well as other odorants. May signal through an inositol 1,4,5-trisphosphate (IP3) second messenger system (By similarity).]
Membrane-spanning 4-domains subfamily A member 4D	Q99N05	[Function: May be involved in signal transduction as a component of a multimeric receptor complex.]
Solute carrier organic anion transporter family member 3A1	Q99N02	[Function: Mediates the Na(+)-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin.]
Vacuolar fusion protein MON1 homolog B	Q8BMQ8
Rieske domain-containing protein	Q8TAC1