Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
RING finger protein 141	Q99MB7	[Function: May be involved in spermatogenesis.]
Dynamin-1-like protein	O00429	[Function: Inhibits peroxisomal division when overexpressed.]
Transcription elongation factor A protein 1	P10711	[Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.]
LIM domain only protein 3	Q99MB5
Nucleolar protein 9	Q8BMC4
Probable C-mannosyltransferase DPY19L1	Q2PZI1	[Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.]
C-C chemokine receptor-like 2	O00421	[Function: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.]
Lysophosphatidic acid receptor 6	Q8BMC0	[Function: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity).]
V-type proton ATPase subunit G 3	Q8BMC1	[Function: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.]
Echinoderm microtubule-associated protein-like 1	O00423	[Function: Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.]
Histone deacetylase complex subunit SAP18	O00422	[Function: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.]
SHC-transforming protein 2	Q8BMC3	[Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.]
Neuronal growth regulator 1	Q80Z24	[Function: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain.]
Rho guanine nucleotide exchange factor 37	A1IGU5	[Function: May act as a guanine nucleotide exchange factor (GEF).]
Oral-facial-digital syndrome 1 protein homolog	Q80Z25	[Function: Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation.]
Rho guanine nucleotide exchange factor 37	A1IGU4	[Function: May act as a guanine nucleotide exchange factor (GEF).]
Rho guanine nucleotide exchange factor 37	A1IGU3	[Function: May act as a guanine nucleotide exchange factor (GEF).]
Mediator of RNA polymerase II transcription subunit 23	Q80YQ2	[Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Also required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.]
Calcipressin-1	Q6IN33	[Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.]
TM2 domain-containing protein 1	Q99MB3	[Function: May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.]