Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Probable tRNA (uracil-O(2)-)-methyltransferase	Q8IYL2	[Function: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.]
Probetacellulin	P35070	[Function: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.]
Rab effector MyRIP	Q8NFW9	[Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity).]
Down syndrome critical region protein 9	P59020
Down syndrome critical region protein 10	P59022
Peptidyl-prolyl cis-trans isomerase FKBP14	P59024	[Function: PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens.]
Transcription elongation factor 1 homolog	P60003	[Function: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.]
Transcription elongation factor 1 homolog	P60002	[Function: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.]
Anaphase-promoting complex subunit 15	P60007	[Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 (By similarity).]
Spermatid-specific linker histone H1-like protein	P60008	[Function: DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.]
Anaphase-promoting complex subunit 15	P60006	[Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.]
Centrin-3	O15182	[Function: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.]
RalBP1-associated Eps domain-containing protein 2	Q8NFH8	[Function: Involved in growth factor signaling through its influence on the Ral signaling pathway.]
Oncostatin-M	P13725	[Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).]
Bone marrow proteoglycan	P13727	[Function: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.]
Tissue factor	P13726	[Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.]
Beta-galactoside alpha-2,6-sialyltransferase 1	P13721	[Function: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.]
Band 4.1-like protein 4B	B2RYE5	[Function: Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18. Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing. May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation.]
Reticulophagy regulator 2	Q6NS82
Mitochondrial amidoxime reducing component 2	Q969Z3	[Function: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045).]