Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
INO80 complex subunit B	Q99PT3	[Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.]
Vacuolar fusion protein MON1 homolog B	Q7L1V2
Probable ATP-dependent RNA helicase DDX52	Q99PT0
BTB/POZ domain-containing protein KCTD9	Q7L273	[Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.]
Rho GDP-dissociation inhibitor 1	Q99PT1	[Function: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.]
Olfactory receptor 1A1	Q9P1Q5	[Function: Odorant receptor.]
Dynein heavy chain 2, axonemal	Q9P225	[Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	A0A0G2K344	[Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology (By similarity). Participates in cellular signaling in response to various growth factors (By similarity). Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinase ligands such as EGF, IGF1, VEGFA and PDGF (By similarity). Also involved in the activation of AKT1 upon stimulation by receptor tyrosine kinase ligand insulin (PubMed:20236230). Involved in signaling via insulin-receptor substrate (IRS) proteins (By similarity). Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity (By similarity). Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF (By similarity). Regulates invadopodia formation through the PDPK1-AKT1 pathway (By similarity). Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway (By similarity). Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway (By similarity). Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS (By similarity). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).]
Rho GTPase-activating protein 23	Q9P227	[Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.]
Putative RRN3-like protein RRN3P1	Q2M238
Helicase POLQ-like	Q8TDG4	[Function: Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase (PubMed:11751861). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904).]
Histidine-rich glycoprotein	Q99PS8	[Function: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity).]
Engulfment and cell motility protein 1	Q8BPU7	[Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).]
Histone-lysine N-methyltransferase SETDB2	Q8C267	[Function: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity).]
NK1 transcription factor-related protein 1	Q15270
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1	Q4LDE5	[Function: May play a role in the cell attachment process.]
Actin-related protein T1	Q8TDG2	[Function: Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.]
Spindle and kinetochore-associated protein 3	Q8C263	[Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.]
Nicotinate-nucleotide pyrophosphorylase [carboxylating]	Q15274	[Function: Involved in the catabolism of quinolinic acid (QA).]
Unconventional myosin-Ih	Q8N1T3	[Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).]