Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Dynein heavy chain 3, axonemal | Q8TD57 | [Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).] |
| IQ domain-containing protein E | Q6PCQ0 | [Function: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:24582806). Required for proper limb morphogenesis (By similarity).] |
| Signal peptide peptidase-like 2A | Q8TCT8 | [Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).] |
| SH2 domain-containing adapter protein B | Q6PD21 | [Function: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells (By similarity).] |
| UPF0462 protein C4orf33 | Q8N1A6 | |
| Armadillo-like helical domain-containing protein 3 | Q6PD19 | [Function: Involved in GBF1 recruitment, Golgi maintenance and protein secretion.] |
| Probable G-protein coupled receptor 156 | Q6PCP7 | [Function: Orphan receptor.] |
| Galectin-4 | P56470 | [Function: Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.] |
| Protein FAM189B | P81408 | |
| Solute carrier family 7 member 13 | Q8TCU3 | [Function: Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.] |
| Alstrom syndrome protein 1 | Q8TCU4 | [Function: Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells.] |
| Glutamate receptor ionotropic, NMDA 3A | Q8TCU5 | [Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).] |
| Mitochondrial uncoupling protein 3 | P56499 | [Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity).] |
| Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial | Q8BPC6 | [Function: Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.] |
| Rab-interacting lysosomal protein | Q5ND29 | [Function: Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.] |
| Scavenger receptor class F member 1 | Q5ND28 | [Function: Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein (By similarity). Plays a role in the regulation of neurite-like outgrowth.] |
| Paraneoplastic antigen Ma1 homolog | Q8C1C8 | |
| Proactivator polypeptide-like 1 | Q8C1C1 | [Function: May activate the lysosomal degradation of sphingolipids.] |
| Mitochondrial fission factor | Q6PCP5 | [Function: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.] |
| Tumor rejection antigen P815A | P19473 |