Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
DNA-binding protein Ikaros	Q03267	[Function: Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells (By similarity). Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity).]
Nucleolar GTP-binding protein 1	Q99P77	[Function: Involved in the biogenesis of the 60S ribosomal subunit.]
Neuroligin-4, X-linked	Q8N0W4	[Function: Putative neuronal cell surface protein involved in cell-cell-interactions.]
Zinc finger protein 567	Q8N184	[Function: May be involved in transcriptional regulation.]
Kinocilin	Q307W7	[Function: May play a role in stabilizing dense microtubular networks or in vesicular trafficking.]
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2	Q8N183	[Function: Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371).]
L-fucose kinase	Q8N0W3	[Function: Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.]
Rhomboid domain-containing protein 3	Q8BP97
Receptor-type tyrosine-protein phosphatase kappa	Q15262	[Function: Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.]
Sperm motility kinase X	Q8C0X8	[Function: May play a role in sperm motility, especially in the regulation of flagellar function.]
IQ domain-containing protein K	Q8N0W5
UPF0500 protein C1orf216 homolog	Q8BP99
Calcium-responsive transcription factor	Q8N187	[Function: Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence.]
Fragile X mental retardation 1 neighbor protein	Q8N0W7
Carbamoyl-phosphate synthase [ammonia], mitochondrial	Q8C196	[Function: Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.]
Serine/threonine-protein phosphatase 4 regulatory subunit 4	Q8C0Y0	[Function: Putative regulatory subunit of serine/threonine-protein phosphatase 4.]
Homeobox protein TGIF2	Q8C0Y1	[Function: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins (By similarity).]
Mitochondrial import receptor subunit TOM7 homolog	Q9P0U1	[Function: Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.]
Sentrin-specific protease 1	Q9P0U3	[Function: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Deconjugates SUMO1 from METTL3 (PubMed:29506078). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844).]
CXXC-type zinc finger protein 1	Q9P0U4	[Function: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.]