Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
SLIT and NTRK-like protein 6	Q8C110	[Function: Regulator of neurite outgrowth required for normal hearing and vision.]
Serine/threonine-protein kinase greatwall	Q8C0P0	[Function: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity).]
Urotensin-2 receptor	Q8VIH9	[Function: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity).]
Protein atonal homolog 7	Q8N100	[Function: Transcription factor involved in the differentiation of retinal ganglion cells.]
Beta-defensin 106	Q8N104	[Function: Has antibacterial activity (PubMed:12600824). Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:23938203).]
Cystatin-14	Q8VIH8	[Function: May play a specialized role in spermatogenesis.]
Olfactory receptor 51E1	Q8TCB6	[Function: Odorant receptor.]
T-cell activation Rho GTPase-activating protein	Q8N103	[Function: May function as a GTPase-activating protein and may play important roles during T-cell activation.]
Cysteine and tyrosine-rich protein 1	Q8VIH7
Matrix metalloproteinase-21	Q8N119	[Function: Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721).]
Cytochrome P450 4X1	Q8N118
Golgin subfamily A member 6-like protein 22	H0YM25
Nuclear receptor subfamily 1 group I member 3	Q9QUS1	[Function: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity).]
Adipocyte enhancer-binding protein 1	Q640N1	[Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.]
A-kinase anchor protein 7 isoform gamma	Q9P0M2	[Function: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.]
Rho GTPase-activating protein 30	Q640N3	[Function: GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.]
Hairy/enhancer-of-split related with YRPW motif protein 2	Q9QUS4	[Function: Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.]
ADP-ribosylation factor-like protein 13B	Q640N2	[Function: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling (PubMed:23817546). Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex (PubMed:23153492).]
Cystatin-14	Q8VII3	[Function: May play a specialized role in spermatogenesis.]
Interleukin-17C	Q9P0M4	[Function: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.]