Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| B-cell CLL/lymphoma 6 member B protein | Q8N143 | [Function: Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.] |
| Condensin complex subunit 2 | Q8C156 | [Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.] |
| Protein-glucosylgalactosylhydroxylysine glucosidase | Q8BP56 | [Function: Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.] |
| Olfactory receptor 8H3 | Q8N146 | [Function: Odorant receptor.] |
| Centromere protein L | Q8N0S6 | [Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.] |
| Leucine-rich repeat LGI family member 3 | Q8N145 | [Function: May participate in the regulation of neuronal exocytosis.] |
| XK-related protein 8 | Q8C0T0 | [Function: Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.] |
| Protein fem-1 homolog A-B | Q8C0T1 | [Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4 (By similarity).] |
| Olfactory receptor 6V1 | Q8N148 | [Function: Odorant receptor.] |
| Terminal nucleotidyltransferase 5B | Q8C152 | [Function: Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.] |
| Heat shock 70 kDa protein 4 | P34932 | |
| Neurotrimin | Q9P121 | [Function: Neural cell adhesion molecule.] |
| Ras association domain-containing protein 3 | Q99P51 | |
| Phosphatidylethanolamine-binding protein 2 | Q8VIN1 | [Function: May bind to phospholipids. May act as serine protease inhibitor (By similarity).] |
| Heat shock 70 kDa protein 1-like | P34931 | [Function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).] |
| Growth hormone secretagogue receptor type 1 | Q99P50 | [Function: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (By similarity).] |
| C-type lectin domain family 1 member B | Q9P126 | [Function: (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).] |
| Leucine zipper protein 4 | Q9P127 | [Function: Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters (PubMed:25662211).] |
| Stereocilin | Q8VIM6 | [Function: Essential to the formation of horizontal top connectors between outer hair cell stereocilia.] |
| Carnitine O-palmitoyltransferase 1, brain isoform | Q8TCG5 | [Function: May play a role in lipid metabolic process.] |