Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Fructose-bisphosphate aldolase C	P09972
Zinc finger protein 564	Q8TBZ8	[Function: May be involved in transcriptional regulation.]
Testis-expressed protein 47	Q8TBZ9
Zinc finger protein 502	Q8TBZ5	[Function: May be involved in transcriptional regulation.]
Furin	P09958	[Function: (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP.]
tRNA methyltransferase 10 homolog A	Q8TBZ6	[Function: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).]
Carboxylesterase 1E	Q64176	[Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.]
Alkyldihydroxyacetonephosphate synthase, peroxisomal	Q8C0I1	[Function: Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.]
Cyclin-dependent kinase-like 2	Q9QUK0
Protein CLN8	Q9QUK3	[Function: Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.]
Synaptic vesicle glycoprotein 2A	Q7L0J3	[Function: (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.]
Heat shock protein beta-7	Q9QUK5
Baculoviral IAP repeat-containing protein 1b	Q9QUK4	[Function: Sensor component of the NLRC4 inflammasome that specifically recognizes and binds type III secretion system (T3SS) rod proteins such as S.typhimurium (Salmonella) PrgJ and B.thailandensis BsaK from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. Prevents motor-neuron apoptosis induced by a variety of signals.]
Coiled-coil domain-containing protein 110	Q8TBZ0
Leukotriene A-4 hydrolase	P09960	[Function: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.]
Toll-like receptor 4	Q9QUK6	[Function: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:9851930, PubMed:9989976, PubMed:20133493). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:24380872). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).]
MYCBP-associated protein	Q8TBZ2	[Function: May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).]
WD repeat-containing protein 20	Q8TBZ3	[Function: Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336).]
Ataxin-7-like protein 3B	Q3UD01	[Function: By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3.]
Zinc finger protein 470	Q6ECI4	[Function: May be involved in transcriptional regulation.]