Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Voltage-dependent calcium channel gamma-5 subunit	Q8VHW4	[Function: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).]
Nucleolar complex protein 3 homolog	Q8VI84	[Function: May be required for adipogenesis.]
Voltage-dependent calcium channel gamma-6 subunit	Q8VHW3	[Function: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.]
Disintegrin and metalloproteinase domain-containing protein 32	Q8TC27	[Function: May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.]
Voltage-dependent calcium channel gamma-4 subunit	Q8VHW9	[Function: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:17880894, PubMed:19234459).]
Enkurin	Q8TC29	[Function: Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.]
Protein kish-A	Q8TBQ9	[Function: Involved in the early part of the secretory pathway.]
Transcription factor AP-2-epsilon	Q6VUC0	[Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).]
T-cell surface glycoprotein CD3 delta chain	P19377	[Function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.]
Voltage-dependent calcium channel gamma-8 subunit	Q8VHW5	[Function: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.]
Voltage-dependent calcium channel gamma-5 subunit	Q8VHW8	[Function: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. According to PubMed:18817736, shows only specificity for GRIA2 and specifically to the form of GRIA2 for which a single amino acid in the pore region has been edited from a glutamine to an arginine residue. Thought to stabilize the calcium channel in an inactivated (closed) state.]
Outer dense fiber protein 4	Q8VI88	[Function: Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.]
Transmembrane protein 163	Q8TC26	[Function: May bind zinc and other divalent cations and recruit them to vesicular organelles.]
Voltage-dependent calcium channel gamma-6 subunit	Q8VHW7	[Function: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.]
Microtubule-associated protein 2	P20357	[Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.]
Collagen alpha-1(IX) chain	Q05722	[Function: Structural component of hyaline cartilage and vitreous of the eye.]
Tissue factor	P20352	[Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.]
Monocarboxylate transporter 11	Q5NC32	[Function: Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.]
2'-5'-oligoadenylate synthase 3	Q8VI93	[Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.]
Ectodysplasin-A receptor-associated adapter protein	Q8VHX2	[Function: Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B (By similarity).]