Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Neurotrophin-4	Q80VU4	[Function: Could serve as a target-derived trophic factor for sensory and sympathetic neurons.]
Proprotein convertase subtilisin/kexin type 9	Q80W65	[Function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.]
Heparan sulfate glucosamine 3-O-sulfotransferase 2	Q80W66	[Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. May contribute to the pineal circadian physiology. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.]
DDB1- and CUL4-associated factor 12-like protein 2	Q5VW00
Son of sevenless homolog 2	Q07890	[Function: Promotes the exchange of Ras-bound GDP by GTP.]
Microtubule-associated serine/threonine-protein kinase 1	Q9R1L5	[Function: Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins.]
Jerky protein homolog-like	B2RRL2
Son of sevenless homolog 1	Q07889	[Function: Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).]
Zinc finger C2HC domain-containing protein 1A	Q8BJH1
Kin of IRRE-like protein 1	Q80W68	[Function: Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.]
Uncharacterized protein C12orf71 homolog	Q80W69
Ubiquitin domain-containing protein UBFD1	O14562	[Function: May play a role as NF-kappa-B regulator.]
PC4 and SFRS1-interacting protein	Q99JF8	[Function: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).]
Cytochrome b561 domain-containing protein 2	O14569	[Function: Two-heme-containing cytochrome that catalyzes ascorbate-dependent trans-membrane ferric-chelate reduction.]
Diphosphomevalonate decarboxylase	Q99JF5	[Function: Performs the first committed step in the biosynthesis of isoprenes.]
Class A basic helix-loop-helix protein 9	Q5RJB0	[Function: Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis.]
Acyl carrier protein, mitochondrial	O14561	[Function: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371).]
Pleckstrin homology domain-containing family A member 8	Q80W71	[Function: Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity).]
Teneurin-2	Q9R1K2	[Function: Induces gene transcription inhibition.]
Eukaryotic translation initiation factor 4E-binding protein 3	Q80VV3	[Function: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.]