Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Nucleoplasmin-2	Q80W85	[Function: Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.]
Roundabout homolog 4	Q80W87	[Function: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).]
Microtubule organization protein AKNA	Q80VW7	[Function: Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (PubMed:30787442). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (PubMed:30787442). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (PubMed:30787442). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (PubMed:30787442). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (By similarity). Binds to A/T-rich promoters (By similarity). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable).]
Tetratricopeptide repeat protein 38	A3KMP2
Homeobox and leucine zipper protein Homez	Q80W88	[Function: May function as a transcriptional regulator.]
Sodium bicarbonate cotransporter 3	Q9R1N3	[Function: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	Q80W83	[Function: As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.]
Collagen alpha-1(XIII) chain	Q9R1N9	[Function: Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625).]
Dol-P-Man_Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase	Q8VDB2	[Function: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.]
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	Q80W89	[Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.]
Ribonuclease P protein subunit p25-like protein	Q99JH1	[Function: May be a component of ribonuclease P or MRP.]
Sodium- and chloride-dependent transporter XTRP3A	Q8VDB9	[Function: Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids.]
Leucine-rich repeat-containing protein 2	Q8VDB8
Hereditary hemochromatosis protein	Q30201	[Function: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.]
ER lumen protein-retaining receptor 1	Q99JH8	[Function: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.]
Calsyntenin-3	Q99JH7	[Function: May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.]
LIM/homeobox protein Lhx9	Q80W90	[Function: Involved in gonadal development.]
Olfactory receptor 7A17	O14581	[Function: Odorant receptor.]
Iron-sulfur cluster assembly 1 homolog, mitochondrial	Q80W96	[Function: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.]
Small glutamine-rich tetratricopeptide repeat-containing protein beta	Q80W98	[Function: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.]