Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Q8VCC1	[Function: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).]
Transmembrane protease serine 7	Q8BIK6	[Function: Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.]
Cerebral cavernous malformations 2 protein-like	Q8VCC6
Cell division control protein 45 homolog	O75419	[Function: Required for initiation of chromosomal DNA replication.]
Spondin-1	Q8VCC9	[Function: Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity).]
Rap guanine nucleotide exchange factor 3	Q8VCC8	[Function: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity).]
Carnosine N-methyltransferase	Q80UY1	[Function: N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).]
F-box only protein 24	O75426	[Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.]
E3 ubiquitin-protein ligase KCMF1	Q80UY2	[Function: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.]
Leucine-rich repeat and calponin homology domain-containing protein 4	O75427
Ret finger protein-like 4A-like protein 1	F8VTS6
Motile sperm domain-containing protein 3	O75425
GRB10-interacting GYF protein 1	O75420	[Function: May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity).]
Sulfide_quinone oxidoreductase, mitochondrial	Q9R112	[Function: Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).]
Guanine deaminase	Q9R111	[Function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.]
Small acidic protein	Q9R0P4
S-formylglutathione hydrolase	Q9R0P3	[Function: Serine hydrolase involved in the detoxification of formaldehyde.]
Signal peptidase complex catalytic subunit SEC11A	Q9R0P6	[Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.]
Destrin	Q9R0P5	[Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.]
Serine protease HTRA1	Q9R118	[Function: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves (PubMed:18551132) or not (PubMed:14973287). By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.]