Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Q9R0E2 | [Function: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (PubMed:27119146). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (PubMed:27119146).] |
| Ankyrin repeat domain-containing protein 13A | Q80UP5 | [Function: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity).] |
| Protein TANC2 | A2A690 | [Function: Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines.] |
| Cleft lip and palate transmembrane protein 1 homolog | Q8VBZ3 | [Function: May play a role in T-cell development.] |
| Late cornified envelope protein 2B | O14633 | [Function: Precursors of the cornified envelope of the stratum corneum.] |
| Dehydrogenase/reductase SDR family member on chromosome X homolog | Q8VBZ0 | [Function: Involved in the positive regulation of starvation-induced autophagy.] |
| Ras association domain-containing protein 6 | Q80UQ2 | [Function: Involved in the induction of apoptosis. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B.] |
| Zinc finger protein 32 | Q80V23 | [Function: May be involved in transcriptional regulation.] |
| Peroxisomal acyl-coenzyme A oxidase 1 | Q9R0H0 | [Function: Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity).] |
| Brain acid soluble protein 1 | Q05175 | |
| Endomucin | Q9R0H2 | [Function: Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.] |
| Transmembrane gamma-carboxyglutamic acid protein 2 | O14669 | |
| Heat shock factor-binding protein 1-like protein 1 | D4A9E1 | |
| Transcription cofactor vestigial-like protein 4 | Q80V24 | [Function: May act as a specific coactivator for the mammalian TEFs.] |
| Keratin, type II cytoskeletal 71 | Q9R0H5 | [Function: Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.] |
| Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase | Q80V26 | [Function: Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate (PubMed:18695242). May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (PubMed:18695242). Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.] |
| Syntaxin-16 | O14662 | [Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.] |
| Transmembrane gamma-carboxyglutamic acid protein 1 | O14668 | |
| Immunoglobulin lambda variable 5-39 | A0A0G2JS06 | [Function: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).] |
| Centrosomal protein of 104 kDa | Q80V31 | [Function: Required for ciliogenesis and for structural integrity at the ciliary tip.] |