Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Caspase-7	P97864	[Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Overexpression promotes programmed cell death (By similarity).]
Rho guanine nucleotide exchange factor 16	Q5VV41	[Function: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.]
Peroxisomal targeting signal 2 receptor	P97865	[Function: Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.]
E3 ubiquitin-protein ligase RBBP6	P97868	[Function: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation (PubMed:17470788). Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).]
Brefeldin A-inhibited guanine nucleotide-exchange protein 2	A2A5R2	[Function: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways (By similarity).]
Dyslexia-associated protein KIAA0319	Q5VV43	[Function: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.]
Probable G-protein coupled receptor 171	O14626	[Function: Orphan receptor.]
C-X-C motif chemokine 11	O14625	[Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.]
Zinc finger protein 195	O14628	[Function: May be involved in transcriptional regulation.]
Mannosyl-oligosaccharide glucosidase	Q80UM7	[Function: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.]
Homeobox protein CDX-4	O14627
N-alpha-acetyltransferase 15, NatA auxiliary subunit	Q80UM3	[Function: Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.]
Calcium channel flower homolog	D4A9I3
Transcobalamin-2	Q9R0D6	[Function: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.]
WD repeat-containing protein 54	Q9R0D8	[Function: When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation.]
Rhomboid-related protein 1	Q8VC82	[Function: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.]
Sodium- and chloride-dependent creatine transporter 1	Q8VBW1	[Function: Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.]
Pleckstrin homology domain-containing family A member 4	Q8VC98	[Function: Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.]
Ankyrin repeat domain-containing protein 20A3	Q5VUR7
C-type lectin domain family 4 member K	Q8VBX4	[Function: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.]