Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Cystatin-like 1	Q80Y72
UPF0722 protein C11orf88 homolog	Q80Y73
Putative transcription factor ovo-like protein 3	O00110	[Function: May act as a transcription regulator.]
DnaJ homolog subfamily B member 13	Q80Y75	[Function: Plays a role in the formation of the central complex of ciliary and flagellar axonemes.]
HIRA-interacting protein 3	Q8BLH7	[Function: May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.]
Deoxyribonuclease-2-alpha	O00115	[Function: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.]
Transmembrane protein 51	Q99LG1
Serine/threonine-protein kinase Chk1	O14757	[Function: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition.]
Transportin-2	Q99LG2	[Function: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).]
Dermatan-sulfate epimerase	Q8BLI4	[Function: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.]
Ubiquitin carboxyl-terminal hydrolase 16	Q99LG0	[Function: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.]
ADAMTS-like protein 1	Q8BLI0
Formiminotransferase N-terminal subdomain-containing protein	E5RQL4
IQCJ-SCHIP1 readthrough transcript protein	A0A088MLT8	[Function: May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25953347, PubMed:25950943, PubMed:27979964). May also play a role in axon outgrowth and guidance (PubMed:25953347).]
Putative transcription factor Ovo-like 1	O14753	[Function: Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).]
17-beta-hydroxysteroid dehydrogenase type 6	O14756	[Function: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.]
Tetratricopeptide repeat protein 5	Q99LG4	[Function: Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2.]
Protein shortage in chiasmata 1 ortholog	Q5VXU9	[Function: ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (PubMed:29742103). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (PubMed:29742103).]
Transmembrane protease serine 13	Q5U405
Heparan sulfate glucosamine 3-O-sulfotransferase 1	O14792	[Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.]