Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Ras-related protein Rab-27B	O00194	[Function: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).]
Tripartite motif-containing protein 77	I1YAP6
Vomeronasal type-1 receptor 93	Q5J3L7	[Function: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.]
Vomeronasal type-1 receptor 100	Q5J3L6	[Function: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.]
C-C motif chemokine 24	O00175	[Function: Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.]
GTP-binding protein 1	O00178	[Function: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).]
Potassium channel subfamily K member 1	O00180	[Function: Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478).]
Smoothelin-like protein 1	Q99LM3	[Function: Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-301 reduces this inhibitory activity.]
Galectin-9	O00182	[Function: Acts as an eosinophil chemoattractant (PubMed:9642261). It also inhibits angiogenesis (PubMed:24333696). Suppresses IFNG production by natural killer cells (By similarity).]
CDK5 regulatory subunit-associated protein 3	Q99LM2	[Function: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1.]
Vomeronasal type-1 receptor A14	Q5J3K9	[Function: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.]
Vomeronasal type-1 receptor 102	Q5J3K5	[Function: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.]
Transcriptional adapter 1	Q99LM9	[Function: Probably involved in transcriptional regulation.]
Potassium-transporting ATPase alpha chain 1	P09626	[Function: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.]
Olfactory receptor 493	Q8VEW5	[Function: Potential odorant receptor.]
Olfactory receptor 510	Q8VEW6	[Function: Potential odorant receptor.]
Homeobox protein Hox-B7	P09629	[Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.]
Olfactory receptor 498	Q8VEW2	[Function: Potential odorant receptor.]
Transmembrane protein 218	Q5U3Y9	[Function: May be involved in ciliary biogenesis or function.]
Cytochrome P450 2G1	P10610	[Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.]