Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Protein TASOR 2 | Q5VWN6 | |
| Tubby-related protein 2 | O00295 | |
| Chloride intracellular channel protein 1 | O00299 | [Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.] |
| Dipeptidyl peptidase 3 | Q99KK7 | [Function: Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro).] |
| Replication protein A 70 kDa DNA-binding subunit | Q8VEE4 | [Function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.] |
| N-acylneuraminate cytidylyltransferase | Q99KK2 | [Function: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).] |
| A-kinase anchor protein 17B | A2A3V1 | [Function: Splice factor regulating alternative splice site selection for certain mRNA precursors.] |
| LIM and cysteine-rich domains protein 1 | Q8VEE1 | [Function: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.] |
| Receptor expression-enhancing protein 3 | Q99KK1 | [Function: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity).] |
| Ribulose-phosphate 3-epimerase | Q8VEE0 | [Function: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.] |
| Probable histidine--tRNA ligase, mitochondrial | Q99KK9 | |
| NACHT, LRR and PYD domains-containing protein 1b allele 4 | Q2LKV2 | [Function: As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (By similarity). Contrary to Nlrp1b allele 1, allele 4 is not activated by Bacillus anthracis lethal toxin and no other activation signal is reported (PubMed:16429160). In addition, allele 4 is missing a CARD domain, which has been shown in other alleles to be involved in the interaction with PYCARD, CASP1 and CASP4/CASP11. It is thus unclear if this allele is able to promote inflammasome assembly.] |
| Transcription initiation factor TFIID subunit 12 | Q8VE65 | [Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (By similarity).] |
| SNF-related serine/threonine-protein kinase | Q8VDU5 | [Function: May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis (By similarity).] |
| G-protein-signaling modulator 2 | Q8VDU0 | [Function: Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions (PubMed:12571286, PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (PubMed:22952234).] |
| Polyadenylate-binding protein-interacting protein 1 | Q8VE62 | [Function: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity).] |
| Tetratricopeptide repeat protein 24 | A2A3L6 | |
| Rho-related GTP-binding protein RhoV | Q8VDU1 | [Function: Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.] |
| Cytochrome b ascorbate-dependent protein 3 | Q5U2W7 | [Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).] |
| Transducin beta-like protein 3 | Q5U2W5 |