Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Transmembrane protein 132A | Q80WF4 | [Function: May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation.] |
| Crossover junction endonuclease EME1 | Q8BJW7 | [Function: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.] |
| Putative insulin-like growth factor 2-associated protein | P09565 | |
| Nuclear receptor subfamily 4 group A member 2 | Q07917 | [Function: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). May confer liver-specific regulation of delayed-early genes induced later in the G1 phase of regeneration along with HMR.] |
| Voltage-dependent anion-selective channel protein 3 | Q9R1Z0 | [Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.] |
| LIM and senescent cell antigen-like-containing domain protein 1 | Q99JW4 | [Function: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.] |
| Alpha/beta hydrolase domain-containing protein 17A | Q99JW1 | [Function: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towars MAP6.] |
| 28S ribosomal protein S23, mitochondrial | Q8VE22 | |
| Aminoacylase-1 | Q99JW2 | [Function: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).] |
| Spermine oxidase | Q99K82 | [Function: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.] |
| Prostaglandin reductase 2 | Q8VDQ1 | [Function: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.] |
| Ras-related protein Rab-1B | P10536 | [Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (PubMed:1918138). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (PubMed:23188820).] |
| NAD-dependent protein deacetylase sirtuin-2 | Q8VDQ8 | [Function: Deacetylates alpha-tubulin.] |
| Protein naked cuticle homolog 2 | Q8VE28 | [Function: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells (By similarity).] |
| Motile sperm domain-containing protein 1 | Q5RJS6 | [Function: Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.] |
| Ribosome production factor 1 | Q5RJS9 | [Function: May be required for ribosome biogenesis.] |
| Protein KRI1 homolog | Q8VDQ9 | |
| Protein FAM216A | Q5U1Y9 | |
| Protein-tyrosine sulfotransferase 2 | Q5RJS8 | [Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.] |
| Endoribonuclease YbeY | P58557 | [Function: Single strand-specific metallo-endoribonuclease involved in rRNA maturation.] |