Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Dolichol kinase	Q8R2Y3	[Function: Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.]
Cell surface glycoprotein MUC18	Q8R2Y2	[Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity).]
Protein B-Myc	Q6P8Z1	[Function: Seems to act as an inhibitor of cellular proliferation.]
Peptidyl-tRNA hydrolase 2, mitochondrial	Q8R2Y8	[Function: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.]
Histone H2B type 1-C/E/G	Q6ZWY9	[Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.]
Thymosin beta-10	Q6ZWY8	[Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).]
Carcinoembryonic antigen-related cell adhesion molecule 16	Q2WEN9	[Function: Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.]
SOSS complex subunit B1	Q8R2Y9	[Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity).]
Ubiquitin-conjugating enzyme E2 D2B	Q6ZWY6	[Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection (By similarity). Plays a role in early maturation of the testis.]
Neurocalcin-delta	P61601	[Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.]
N-alpha-acetyltransferase 20	P61600	[Function: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.]
GPI mannosyltransferase 2	Q5KR61	[Function: Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).]
40S ribosomal protein S27-like	Q6ZWY3
von Willebrand factor A domain-containing protein 1	Q8R2Z5	[Function: Promotes matrix assembly.]
Calcyphosin-like protein	Q6P8Y1
Anion exchange transporter	Q8R2Z3	[Function: Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion.]
Cilia- and flagella-associated protein 161	Q6P8Y0	[Function: May play a role in motile cilia function, possibly by acting on dynein arm assembly.]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein	Q6IEG0	[Function: Likely involved in U12-type 5' splice site recognition.]
Eukaryotic translation initiation factor 2 subunit 1	Q6ZWX6	[Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).]
Sorting nexin-31	Q6P8Y7	[Function: May be involved in protein trafficking.]