Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
High mobility group protein B4	Q6P8W9
Protein transport protein Sec61 subunit alpha isoform 1	P61619	[Function: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).]
Transmembrane protein 132E	Q6IEE7	[Function: Required for normal inner ear hair cell function and hearing.]
Palmitoleoyl-protein carboxylesterase NOTUM	Q6P988	[Function: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).]
60S ribosomal protein L10	Q6ZWV3	[Function: Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.]
60S ribosomal protein L35	Q6ZWV7	[Function: Component of the large ribosomal subunit.]
GTPase IMAP family member 6	Q6P9H5
Connector enhancer of kinase suppressor of ras 3	Q6P9H4	[Function: Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).]
Zinc finger protein 449	Q6P9G9	[Function: May be involved in transcriptional regulation.]
Homeobox protein Hox-B5	P09079	[Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.]
Transcription elongation factor A N-terminal and central domain-containing protein 2	Q8R2M0
Myogenic factor 5	P24699	[Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.]
Methylmalonyl-CoA mutase, mitochondrial	P22033	[Function: Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species.]
Deoxynucleotidyltransferase terminal-interacting protein 2	Q8R2M2	[Function: Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (By similarity).]
Transmembrane protein 154	Q6P9G4
Cytochrome b5 domain-containing protein 1	Q6P9G0
Olfactory receptor 2A2	Q6IF42	[Function: Odorant receptor.]
Homeobox protein engrailed-1	P09065
Volume-regulated anion channel subunit LRRC8B	Q6P9F7	[Function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).]
Aquaporin-3	Q8R2N1	[Function: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.]