Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Rho GTPase-activating protein 15	Q811M1	[Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity).]
Serine/threonine-protein phosphatase PGAM5, mitochondrial	Q562B5	[Function: Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression (By similarity). Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.]
Protein WFDC9	Q6IE41
WAP four-disulfide core domain protein 12	Q6IE40	[Function: Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity).]
Nucleus accumbens-associated protein 2	Q562B4	[Function: Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity).]
Pleckstrin homology domain-containing family M member 3	Q6ZWE6	[Function: Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation.]
Serine protease inhibitor Kazal-type 7	Q6IE32	[Function: Probable serine protease inhibitor.]
Complement component C6	Q811M5	[Function: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.]
Serine protease inhibitor Kazal-type 14	Q6IE38	[Function: May be a serine protease inhibitor.]
Ovostatin homolog 1	Q6IE37	[Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.]
Ovostatin homolog 2	Q6IE36	[Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	Q4KWH8	[Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.]
Ubiquitin-associated domain-containing protein 2	Q8R1K1	[Function: Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040).]
Angiopoietin-like protein 8	Q8R1L8	[Function: Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577, PubMed:24043787). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (PubMed:24043787). According to a report, may act by promoting ANGPTL3 cleavage (PubMed:23150577). According to another study, not required for cleavage of ANGPTL3 (PubMed:24043787).]
Leucine zipper transcription factor-like protein 1	Q562C6	[Function: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function (By similarity).]
Pumilio homolog 3	Q562C7	[Function: Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells.]
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	Q562C9	[Function: Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14 (By similarity). Induces apoptosis when overexpressed.]
Ribosome biogenesis protein BOP1	Q562C2	[Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.]
Methyltransferase-like protein 7B	Q562C4	[Function: Probable methyltransferase.]
OTU domain-containing protein 6A	Q6IE21	[Function: Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains (By similarity).]