Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Stabilin-1	Q8R4Y4	[Function: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system (By similarity).]
NIPA-like protein 3	Q8BGN5
U1 small nuclear ribonucleoprotein C	P09234	[Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.]
Transmembrane gamma-carboxyglutamic acid protein 4	Q8BGN6	[Function: May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity).]
Rotatin	Q8R4Y8	[Function: Involved in the genetic cascade that governs left-right specification. Required for correct asymmetric expression of NODAL, LEFTY and PITX2 (By similarity).]
Deoxyribonuclease-1	P24855	[Function: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).]
Fructose-bisphosphate aldolase B	P00884
Synaptoporin	Q8BGN8	[Function: Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity).]
Matrilysin	P09237	[Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.]
Stromelysin-2	P09238	[Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.]
UPF0462 protein C4orf33 homolog	Q8BGN2
Interferon alpha-9	P09235	[Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.]
Glycerophosphocholine cholinephosphodiesterase ENPP6	Q8BGN3	[Function: Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404, PubMed:26888014). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids (PubMed:15788404). In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (PubMed:15788404).]
Protein kinase C zeta type	P09217	[Function: Involved in late synaptic long term potentiation phase in CA1 hippocampal cells and long term memory maintenance.]
2-aminomuconic semialdehyde dehydrogenase	Q8BH00	[Function: Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.]
Transmembrane and coiled-coil domain-containing protein 3	Q8BH01	[Function: Probable Na(+)/H(+) antiporter.]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	O75251	[Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.]
Serpin A12	Q8R4Z1	[Function: Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.]
Lysophosphatidylcholine acyltransferase 1	Q1HAQ0	[Function: Possesses both acyltransferase and acetyltransferase activities (PubMed:16864775). Activity is calcium-independent (By similarity). Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (PubMed:16864775). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16864775). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16864775). Involved in the regulation of lipid droplet number and size (By similarity).]
ETS translocation variant 3	Q8R4Z4	[Function: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.]