Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Dynein heavy chain 17, axonemal	Q69Z23	[Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).]
Contactin-4	Q69Z26	[Function: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.]
Cytospin-A	Q69YQ0	[Function: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.]
von Willebrand factor A domain-containing protein 3A	A1A5Q7
Diacylglycerol kinase kappa	Q5KSL6	[Function: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).]
Sperm motility kinase	A1A5Q6	[Function: May play a role in sperm motility, especially in the regulation of flagellar function.]
Lysine-specific demethylase 4D	A1A5Q5	[Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).]
Cilia- and flagella-associated protein 206	A1A5Q4	[Function: May regulate cilium motility through its role in the assembly of the axonemal radial spokes.]
T cell receptor beta joining 1-5	A0A0J9YXM7	[Function: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).]
Leiomodin-2	A1A5Q0	[Function: Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713).]
T-cell acute lymphocytic leukemia protein 1 homolog	P22091	[Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.]
40S ribosomal protein S4, Y isoform 1	P22090
Outer dense fiber protein 3-like protein 2	Q3TZ65
Probable cation-transporting ATPase 13A5	Q3TYU2
Uncharacterized protein KIAA1841 homolog	A1A5R8
RNA exonuclease 5	A1A5R7
LHFPL tetraspan subfamily member 2 protein	Q8BGA2	[Function: Plays a role in female and male fertility. Involved in distal reproductive tract development (PubMed:26964900).]
Leucine-rich repeat transmembrane neuronal protein 2	Q8BGA3	[Function: Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).]
Sperm-tail PG-rich repeat-containing protein 2	A1A5R9
rRNA 2'-O-methyltransferase fibrillarin	P22087	[Function: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:24352239, PubMed:30540930). Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:30540930). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239, PubMed:30540930).]