Terminology Service < Semantic Lookup Platform

All terms in BAO

Label	Id	Description
nerve growth factor stimulator	CHEBI_72294
fuel additive	CHEBI_62803
antiparathyroid drug	CHEBI_50827
primary cutaneous amyloidosis	DOID_0050639	[An amyloidosis characterized by pruritus, skin scratching and by deposits of amyloid in the dermis.]
non-competitive inhibition	BAO_0000485	[A noncompetitive inhibitor binds equally well to both free enzyme and the enzyme-substrate complex. These binding events occur exclusively at a site distinct from the precise active site occupied by substrate. It will lower the apparent Vmax value, yet there is no effect on the apparent KM value for its substrate. Essentially, the KI of the inhibitor does not change as a function of the substrate concentration.]
uncompetitive inhibition	BAO_0000483	[An uncompetitive inhibitor binds exclusively to the enzyme-substrate complex yielding an inactive enzyme-substrate-inhibitor complex. When encountered, the apparent Vmax value and the apparent KM value should both decrease.]
competitive inhibition	BAO_0000482	[A competitive inhibitor binds only to free enzyme. Often this binding event occurs on the active site of the target, precisely where substrate also binds. It will raise the apparent KM value for its substrate with no change in the apparent Vmax value. As a result, competitive inhibition can be overcome, observed by an increase in the apparent KI value, at higher concentrations of substrate.]
kcat	BAO_0000481	[Turnover number representing the maximum number of substrate molecules converted to products per active site per unit time.]
kon	BAO_0000480	[The on-rate associated with the formation of an enzyme-inhibitor complex.]
oculocutaneous albinism	DOID_0050632	[An autosomal recessive disease characterized by abnormal pigmentation of the skin, hair and eyes.]
Allan-Herndon-Dudley syndrome	DOID_0050631	[An X-linked disease that has material basis in mutation at is in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement.]
ocular albinism	DOID_0050633
trichomoniasis	DOID_1947	[A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively.]
growth hormone	CHEBI_37845
partial inhibition	BAO_0000488	[Partial inhibition results from the formation of an enzyme-substrate-inhibitor complex that can generate product with less efficiency than the enzyme-substrate complex.]
osteomalacia	DOID_10573	[A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone.]
Aicardi-Goutieres syndrome	DOID_0050629	[An autosomal recessive disease that is a genetically heterogeneous encephalopathy characterized in its most severe form by cerebral atrophy, leukodystrophy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infections.]
riboswitch	BAO_0000498	[They are part of mRNA that regulate gene expression through ligand induced changes in mRNA secondary or tertiary structure. The ligand is generally a small metabolite which binds to the aptamer part of the riboswitch.]
peptide aptamer	BAO_0000497	[Aptamers are synthetic affinity probes. Peptide aptamers consist of a variable peptide loop attached at both ends of a protein scaffold, such as thioredoxin-A. They bind to target proteins with high affinity, similar to that of an antibody. They are designed to inhibit the function of other protein inside the cell.]
RNA aptamer	BAO_0000496	[Aptamers are synthetic affinity probes. RNA aptamers are oligonucleotides that bind to a specific target molecule such as small molecules, proteins, nucleic acids and cells. They are created by selecting them from a large random sequence pool, but natural aptamers also exist in riboswitches.]