Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Essential_Amino_Acid	NCIT_C68614	[Property used to indicate that an amino acid is essential and must be included in the diet.]
EGFRvIII Peptide	NCIT_C29017	[A synthetic peptide sequence derived from the tumor specific mutant variant of epidermal growth factor receptor EGFRvIII originally found in glioblastoma multiforme, caused by the deletion of exons 2-7. Unlike wild-type EGFR, EGFRvIII is a dominant oncogene that can directly lead to cancer. EGFRvIII is expressed in multiple cancer types including breast, ovarian, and metastatic prostate cancers, and other types of solid tumors due to alternative splicing; has not been observed in normal human tissues. Vaccination with EGFRvIII peptide may stimulate the host immune system to mount a cytotoxic T lymphocyte response against tumor cells positive for EGFRvIII, resulting in decreased tumor growth. (NCI04)]
Transcription Coregulator Gene	NCIT_C20710	[RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. A second group of cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription. A third group of factors suppress transcription. The combined action of general and gene-specific regulators encoded by transcription coactivator genes determines appropriate gene expression. (NCI)]
Emetine Hydrochloride	NCIT_C29018	[The chloride salt of a white crystalline bitter alkaloid isolated from the root of the plant Psychotria Ipecacuanha (ipecac root) and other plants with antiemetic and anthelminthic properties. Emetine inhibits protein synthesis in eukaryotic (but not prokaryotic) cells by irreversibly blocking ribosome movement along the mRNA strand and inhibits DNA replication in the early S phase of the cell cycle. (NCI04)]
Protein Synthesis Inhibitor	NCIT_C784	[A pharmacological agent that inhibits the protein translation process. Protein synthesis inhibitors may be used therapeutically as antibacterial or bacteriostatic agents.]
Unknown Primary Tumor cN2b TNM Finding v8	NCIT_C132660	[Unknown primary tumor with metastases in multiple ipsilateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)]
X-Chromosome Inactivation	NCIT_C20674	[A human early embryonic event in which in any given cell one of a female's two X chromosomes becomes inactivated and converted into a Barr body. After inactivation has occurred, all descendants of that cell have the same inactivated X chromosome. Thus, X-inactivation creates cell clones with differing effective gene content. An organism whose cells vary in effective gene content and hence in the expression of a trait, is called a genetic mosaic.]
Chromosome X	NCIT_C13285	[The sex chromosome that is present in both sexes: singly in males and doubly in females.]
Emofolin Sodium	NCIT_C29019	[The sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity. Emfolin sodium competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, depletion of nucleotide pools, and inhibition of DNA, RNA and protein synthesis. (NCI04)]
Unknown Primary Tumor cN2c TNM Finding v8	NCIT_C132661	[Unknown primary tumor with metastases in bilateral or contralateral cervical lymph nodes, none larger than 6 cm in greatest dimension, ENE(-). (from AJCC 8th Ed.)]
SUB1 Gene	NCIT_C20675	[This gene is involved in mediating transcription induced by upstream activators.]
Conditionally Related to Intervention	NCIT_C68618	[A characteristic used to qualify the adverse event as unclassified in term of its relation to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to clinical event, including laboratory test abnormality, reported as an adverse reaction, about which more data is essential for a proper assessment or the additional data are under examination.]
PSIP1 Gene	NCIT_C20676	[This gene is involved in regulation of transcription. It also plays a role in mediation of pre-mRNA splicing.]
Unknown Primary Tumor cN3a TNM Finding v8	NCIT_C132663	[Unknown primary tumor with metastasis in a cervical lymph node larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)]
Electrolaryngeal Speech	NCIT_C20680
Alaryngeal Speech	NCIT_C17159	[Instructional activity designed to teach patients how to vocalize with a non-functioning or absent larynx.]
Tracheoesophageal Speech	NCIT_C20681
MED1 Gene	NCIT_C20682	[This gene plays a role in the transcriptional activation of target genes. It is involved in embryonic fibroblast differentiation and normal development of vital organs.]
MED14 Gene	NCIT_C20683	[This gene plays a role in activation of Sp1 transcription. It is also involved in vitamin D and thyroid hormone binding.]
Sp1 Activation Cofactor Gene	NCIT_C20686	[Sp1 Activation Cofactor Genes encode (at least 9) protein subunits of the CRSP (Cofactor Required for SP1 activation) complex, which, along with TFIID, is required for efficient activation of gene transcription by SP1, a transcription factor that recognizes enhancer sites in target DNA. Many CRSP complex proteins are also components of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (NCI)]