Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Dechallenge	NCIT_C68620	[The withdrawal of a medical intervention.]
Withdraw	NCIT_C38061	[To cease active participation in; remove from active use.]
Rechallenge	NCIT_C68621	[Reintroduction of previously withdrawn medical intervention in the same patient.]
Melphalan Flufenamide	NCIT_C107680	[A melphalan prodrug in which the alkylating agent melphalan is bound to flufenamide, with potential antineoplastic and anti-angiogenic activities. Upon administration, the dipeptide bond in the melphalan-flufenamide compound is hydrolyzed by peptidases, which are overexpressed by certain cancer cells. This results in the specific release and accumulation of the active metabolite melphalan in cancer cells. Melphalan alkylates DNA at the N7 position of guanine residues and induces DNA intra- and inter-strand cross-linkages. This results in the inhibition of DNA and RNA synthesis and the induction of apoptosis, thereby inhibiting tumor cell proliferation. The administration of the melphalan-flufenamide prodrug allows for enhanced efficacy and reduced toxicity compared to melphalan alone.]
Tumor Cell-derived Dribbles Vaccine	NCIT_C107681	[An autophagosome-enriched cancer vaccine composed of short lived proteins (SLiPs) and defective ribosomal products (DRiPs) derived from tumor cells, with potential immunostimulating and antineoplastic activities. The Dribbles are DriPs- and SLiPs-filled autophagosomes that are made by treating cancer cells with both a proteasome inhibitor, to prevent protein degradation, and an autophagy inducer, which causes the accumulation of DriPs, SLiPs, and their immunogenic fragments. Upon administration of a Dribbles vaccine, the proteins or antigen fragments in Dribbles may stimulate the immune system to mount cytotoxic T-lymphocyte (CTL) and helper T-lymphocyte responses against the cancer-associated antigens (TAAs).]
Substance P-Saporin	NCIT_C107682	[An agent composed of substance P (SP) conjugated to the ribosome-inactivating protein and neurotoxin saporin (SAP), isolated from the seeds of the plant Saponaria officinalis (SP-SAP), with potential analgesic activity. Upon administration, SP-SAP targets the SP receptor, neurokinin-1 receptor (NK-1R), located on neurons. When SP-SAP binds NK-1R and the receptor/conjugate complex internalizes, the saporin moiety inactivates ribosomes and prevents protein synthesis, which causes cell death, destroys NK-1R-expressing nerves and decreases pain perception.]
Anti-FGFR2 Antibody BAY1179470	NCIT_C107683	[An antibody against the fibroblast growth factor receptor type 2 (FGFR2), with potential antineoplastic activity. Upon administration, the anti-FGFR2 antibody BAY1179470 binds to and inhibits FGFR2, which may result in the inhibition of both FGFR2 phosphorylation and FGFR2-mediated signal transduction pathways. This results in the inhibition of cell proliferation and the induction of cell death of FGFR2-expressing tumor cells. FGFR2, upregulated in many tumor cell types, is a receptor tyrosine kinase, which is essential to tumor cellular proliferation, differentiation and survival.]
PI3Kbeta Inhibitor AZD8186	NCIT_C107684	[An inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation and induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents.]
BC-819 Plasmid/Polyethylenimine Complex	NCIT_C107685	[A plasmid DNA encoding for the A fragment of Diphtheria Toxin (DTA) under the control of the H19 gene promoter (BC-819 or DTA-H19) and mixed with the transfectant polyethylenimine (PEI), with potential antineoplastic activity. Upon administration, the PEI moiety enhances the entry of the agent into rapidly dividing cells. Upon cell entry, activation of the H19 gene promoter-containing plasmids and DTA expression are limited to tumor cells, as high levels of H19 expression are only found in tumor cells. DTA disrupts protein synthesis. Tumor-cell selective expression of this toxin leads to the selective destruction of the tumor while sparing healthy, normal cells. H19, an oncofetal, regulatory RNA, is overexpressed in certain cancer cells while its expression in normal cells is minimal or absent; it plays a key role in cancer progression, angiogenesis and metastasis.]
TSQM Version 1.4 - Satisfied or Dissatisfied With Medication	NCIT_C132631	[Treatment Satisfaction Questionnaire for Medication Version 1.4 (TSQM Version 1.4) Taking all things into account, how satisfied or dissatisfied are you with this medication?]
Equilin	NCIT_C29020	[A naturally occurring steroid with estrogenic activity obtained from the urine of pregnant mares.]
Estrogen	NCIT_C2293
Head and Neck Cancer Clinical Regional Lymph Nodes TNM Finding v8	NCIT_C132634	[A clinical finding about one or more characteristics of head and neck cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.]
Head and Neck Cancer cN2 TNM Finding v8	NCIT_C132635	[Head and neck cancer with metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE (extranodal extension)(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension, ENE(-). (from AJCC 8th Ed.)]
Homidium Chloride	NCIT_C29022	[The chloride salt of ethidium (a fluorochrome), Ethidium Chloride intercalates within double-stranded nucleic acids, particularly DNA. In molecular biology, the bromide salt of ethidium is used to detect and visualize DNA after electrophoresis or in cytochemical preparations. In veterinary pharmacology, it is used as a trypanosomicide. Ethidium bromide and chloride are toxic substances and potent noncompetitive antagonists of the nicotinic acetylcholine receptor. (NCI04)]
DNA Intercalating Agent	NCIT_C582
Head and Neck Cancer cN2a TNM Finding v8	NCIT_C132636	[Head and neck cancer with metastasis in a single ipsilateral or contralateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)]
Etiocholanolone	NCIT_C29023	[A 17-ketosteroid which excreted in the urine as a metabolite of steroid hormones. The most common form of etiocholanolone present in the urine is the sulfate salt. This agent, also known as 5-isoandrosterone, may be used to evaluate adrenal cortex function, bone marrow performance and, in neoplastic disease, for immunostimulation. (NCI04)]
Head and Neck Cancer cN2b TNM Finding v8	NCIT_C132637	[Head and neck cancer with metastasis in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)]
EWS/FLI 1 Type 4	NCIT_C29024	[The type 4 form of EWS/FLI-1, an oncogenic fusion gene found in Ewing's sarcoma and primitive neuro-ectodermal tumor (PNET). Resulting from a t(11;22) chromosomal translocation, EWS/FLI 1 appears to play an integral role in the development of Ewing's sarcoma and PNET; the type 4 form of this gene has been shown to transform non-neoplastic cells. EWS/FLI 1 type 4 represents a potential target for antisense oligonucleotide therapy of Ewing's sarcoma and PNET. (NCI04)]