Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Head and Neck Cancer cN2c TNM Finding v8	NCIT_C132638	[Head and neck cancer with metastasis in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)]
EWS/FLI 1 Type 8	NCIT_C29025	[An antisense oligonucleotide that targets the type 8 form of EWS/FLI-1, an oncogenic fusion gene found in Ewing's sarcoma and primitive neuro-ectodermal tumor that results from a t(11;22) chromosomal translocation. EWS/FLI 1 type 8 antisense oligonucleotide inhibits the expression of the EWS/FLI 1 type 8 gene and/or the translation of EWS/FLI 1 type 8 mRNA, thereby down-regulating the abnormal transcription factor and inhibiting tumor cell growth and tumorigenicity. (NCI04)]
MED17 Gene	NCIT_C20688	[This gene is involved in coactivation of Sp1 transcription. It also plays a role in vitamin D and thyroid hormone binding.]
Echinacea Extract	NCIT_C29026	[An over-the-counter herbal remedy, extracted from North American herb purple coneflower belonging to the Family Asteraceae, with potential immunostimulating and anti-inflammatory activities. Echinacea extract might be helpful to boost the body's immune system and to help fight infections, especially those of the upper respiratory tract. This herbal remedy seems to increase the growth and activity of immune cells, including white blood cells, macrophages and natural killer cells, and to stimulate phagocytosis. Furthermore, echinacoside, one of the components in Echinacea extract, has been shown to inhibit hyaluronidase, whose action increases tissue permeability, thereby Echinacea extract may promote tissue growth for wound healing by preventing bacteria spreading into healthy cells.]
MED26 Gene	NCIT_C20689	[This gene plays a role in the activation of Sp1 transcription.]
Efavirenz	NCIT_C29027	[A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism.]
Entex	NCIT_C29028	[A commercial combination preparation containing guaifenesin and phenylephrine hydrochloride with expectorant and decongestant activities. Guaifenesin works by drawing water into respiratory tracts, thereby reducing adhesiveness and surface tension of mucus as well as increasing hydration of mucus. This reduces the viscosity of mucus and makes the cough more productive. Phenylephrine hydrochloride, a direct-acting sympathicomimetic amine, activates alpha-adrenergic receptors in the nasal mucosa thereby causing vasoconstriction, reduces swelling of nasal mucous membranes and decreases nasal and sinus congestion.]
Ergocalciferol	NCIT_C29029	[Vitamin D2, a fat-soluble vitamin important for many biochemical processes including the absorption and metabolism of calcium and phosphorus. In vivo, ergocalciferol is formed after sun (ultraviolet) irradiation of plant-derived ergosterol, another form of vitamin D. Ergocalciferol is the form of vitamin D usually found in vitamin supplements. (NCI04)]
Secretogranin-1	NCIT_C20684	[Secretogranin-1 (677 aa, ~78 kDa) is encoded by the human CHGB gene. This protein may play a role in the synthesis of biologically active peptides.]
Chromogranin	NCIT_C16436	[Chromogranins are acidic secretory glycoproteins with a widespread but specific distribution in neuroendocrine tissues. The chromogranin family is heterogenous, consisting of propeptides such as chromogranin-A, chromogranin-B and secretogranin II, which can either elicit an effect themselves, or serve as precursors to a large number of peptides, which are biologically more active.]
Monocyte	NCIT_C12547	[Large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.]
Neutrophil	NCIT_C12533	[Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.]
Tumor Marker	NCIT_C17220	[A substance present in or produced by a tumor or by the host, that can be used for differentiating neoplastic from normal tissue based on measurements in body fluids, secretions, cells, and/or tissues. Markers are used in diagnosis, staging and prognosis of cancer, provide an estimation of tumor burden, and serve for monitoring effects of therapy, detecting recurrence, localization of tumors, and screening in general populations.]
Secretogranin-2	NCIT_C20685	[Secretogranin-2 (617 aa, ~71 kDa) is encoded by the human SCG2 gene. This protein is involved in chemotaxis, apoptosis and both proliferation and migration of endothelial cells.]
MED23 Gene	NCIT_C20687	[This gene is involved in activation of Sp1 transcription. It also plays a role in suppression of metastasis.]
TSQM Version 1.4 - Certain Good Things Outweigh Bad	NCIT_C132630	[Treatment Satisfaction Questionnaire for Medication Version 1.4 (TSQM Version 1.4) How certain are you that the good things about your medication outweigh the bad things?]
MED7 Gene	NCIT_C20691	[This gene plays a role in coactivation of Sp1 transcription.]
Nuclear Receptor Coactivator Gene	NCIT_C20692	[Nuclear receptor coactivator genes encode a class of proteins that are recruited and serve as bridging molecules between the transcription initiation complex and nuclear receptors (NRs). Most of these coactivators interact with the AF-2 domain of NRs through one or several LXXLL motifs called NR box. Members of NRs includes the 5 steroid receptors and class II nuclear receptors. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation. (NCI)]
Intermediate Filament	NCIT_C13248	[A class of tough protein filaments (including keratin filaments, neurofilaments, desmin, and vimentin) that measure 8-10 nm in thickness and comprise part of the cytoskeleton of the cytoplasm of most eukaryotic cells; so named because they are intermediate in thickness between actin filaments and microtubules.]
Scaffolding Protein	NCIT_C38764	[Scaffolding Proteins participate in many cellular functions by serving as a supportive base that spatially or temporally organizes, juxtaposes, regulates, and/or promotes the function of other cellular elements (usually proteins). (NCI)]