Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
EZR wt Allele	NCIT_C68723	[Human EZR wild-type allele is located within 6q25.2-q26 and is approximately 54 kb in length. This allele, which encodes ezrin protein, is involved in the regulation of cellular structure, adhesion and migration. The allele is expressed aberrantly at elevated levels in metastatic cells.]
6q25.2-q26	NCIT_C68728	[A chromosome band present on 6q]
CLCA2 Gene	NCIT_C20789	[This gene is involved in the regulation of calcium-activated chloride channel transport.]
Cystic Fibrosis	NCIT_C2975	[A congenital, autosomal, metabolic disorder affecting the exocrine glands. The secretions of exocrine glands are abnormal, resulting in excessively viscid mucus production that causes obstruction of passageways, including pancreatic and bile ducts, intestines, and bronchi. Symptoms usually appear in childhood, and include meconium ileus, poor growth despite good appetite, malabsorption and foul bulky stools, chronic bronchitis with cough, recurrent pneumonia, bronchiectasis, emphysema, clubbing of the fingers, and salt depletion in hot weather secondary to increased sodium and chloride concentration in sweat.]
Insulin, Ultralente	NCIT_C29126	[A long-acting form of crystalline insulin often used in combination with a short-acting insulin in the treatment of diabetes mellitus. Administered once daily, this type of insulin may be derived from porcine, bovine, or recombinant sources. Endogenous human insulin, a pancreatic hormone composed of two polypeptide chains, is important for the normal metabolism of carbohydrates, proteins and fats; it has anabolic effects on many types of tissues. (NCI04)]
Ezrin	NCIT_C68724	[Ezrin protein (586 aa, ~69 kDa) is encoded by the human EZR gene. This protein plays a role in mediating the interaction of the plasma membrane with the actin cytoskeleton; thus, it regulates processes such as microvilli formation and cell migration.]
Iodinated I-131 Serum Albumin	NCIT_C29127	[A synthetic radiopharmaceutical in which human serum albumin (HSA) is radiolabelled with iodine 131. Upon intravenous injection, iodine-131 human serum albumin is slowly deiodinated in vivo, releasing radioactive iodide that is taken up by thyroid gland. Iodine-131 primarily emits beta particles and has a half-life of 8 days. (NCI04)]
Hash Value	NCIT_C68725	[An irreversible unique number generated from a string of text. The hash value is calculated so that it's unlikely, but not impossible, for some other text string to result in the same hash value, but the calculation guarantees that the same string will always produce the same hash value.]
DLC1 Gene	NCIT_C20783	[This gene plays a role in cytoskeletal organization and regulation of cell growth.]
Ipratropium Bromide	NCIT_C29128	[The bromide salt form of ipratropium, a synthetic derivative of the alkaloid atropine with anticholinergic properties. Ipratropium antagonizes the actions of acetylcholine at parasympathetic, postganglionic, effector-cell junctions. When inhaled, ipratropium binds competitively to cholinergic receptors in the bronchial smooth muscle thereby blocking the bronchoconstrictor actions of the acetylcholine mediated vagal impulses. Inhibition of the vagal tone leads to dilation of the large central airways resulting in bronchodilation.]
Epithelial Protein Up-Regulated in Carcinoma, Membrane Associated Protein 17 Gene	NCIT_C20784
Ipratropium/Albuterol	NCIT_C29129	[A combination of albuterol and ipratropium with a bronchodilatory effect. Albuterol stimulates beta-2 adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'- adenosine monophosphate (cAMP). This results in the relaxation of bronchial smooth muscle, relieve of bronchospasms, and reduction of inflammatory cell mediator release. Ipratropium is a synthetic quaternary ammonium compound and a competitive muscarinic acetylcholine (Ach) receptor antagonist. This agent inhibits vagally mediated reflexes by antagonizing the action of Ach and consequently, prevents the increase in intracellular cyclic guanosine monophosphate, which is a result of ACh interacting with the muscarinic receptor on bronchial smooth muscle.]
ALOX5 wt Allele	NCIT_C68727	[Human ALOX5 wild-type allele is located in the vicinity of 10q11.2 and is approximately 72 kb in length. This allele, which encodes arachidonate 5-lipoxygenase protein, is involved in the regulation of leukotriene signaling. Mutations in the gene, which affect the enzymatic activity of the gene product, play a role in asthma, atherosclerosis and several cancers.]
10q11.2	NCIT_C13610	[A chromosome band present on 10q]
Myeloproliferative Neoplasm	NCIT_C4345	[A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)]
6q	NCIT_C13560	[Distal (long) arm of chromosome 6]
FBXW7 Gene	NCIT_C20786	[This gene is involved in ubiquitin-dependent proteolysis and regulation of the G1-S cell cycle checkpoint.]
HYOU1 Gene	NCIT_C20790	[This gene plays in the regulation of cellular response to ischemic stress conditions.]
Cytoplasmic Protein Gene	NCIT_C25969	[Cytoplasmic Protein Genes encode Cytoplasmic Proteins that are typically localized in the cell interior, generally excluding the plasma membrane, mitochondria, and the nucleus. (NCI)]
CDKN2A NP_000068.1:p.D108H	NCIT_C146942	[A change in the amino acid residue at position 108 in the cyclin-dependent kinase inhibitor 2 protein where aspartic acid has been replaced by histidine.]